Variables | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Surgery | ||||
No | 1 | 1 | ||
Yes | 0.435 (0.382–0.496) | < 0.001 | 0.492 (0.427–0.567) | < 0.001 |
Year of diagnosis | ||||
2004–2009 | 1 | |||
2010–2015 | 0.967 (0.878–1.065) | 0.497 | ||
Age | ||||
< 65 years old | 1 | 1 | ||
> = 65 years old | 1.243 (1.130–1.368) | < 0.001 | 1.102 (0.998–1.217) | 0.055 |
Sex | ||||
Male | 1 | |||
Female | 1.039 (0.928–1.163) | 0.504 | ||
Race | ||||
White | 1 | 1 | ||
Black | 1.375 (1.217–1.555) | < 0.001 | 1.060 (0.925–1.214) | 0.401 |
Other/unknown | 0.925 (0.767–1.115) | 0.412 | 0.809 (0.668–0.980) | 0.031 |
Primary site | ||||
Upper third | 1 | 1 | ||
Middle third | 1.190 (1.015–1.396) | 0.033 | 1.283 (1.090–1.510) | 0.003 |
Lower third | 0.857 (0.747–0.982) | 0.027 | 1.105 (0.938–1.301) | 0.233 |
Unknown | 1.260 (1.072–1.481) | 0.005 | 1.198 (1.012–1.417) | 0.035 |
Histology | ||||
Adenocarcinoma | 1 | 1 | ||
Squamous cell carcinoma | 1.408 (1.274–1.556) | < 0.001 | 1.347 (1.177–1.542) | < 0.001 |
Other | 1.671 (1.383–2.021) | < 0.001 | 1.376 (1.128–1.678) | 0.002 |
Differentiation | ||||
Grade I | 1 | 1 | ||
Grade II | 1.175 (0.911–1.517) | 0.214 | 1.187 (0.918–1.535) | 0.191 |
Grade III/IV | 1.365 (1.060–1.756) | 0.016 | 1.464 (1.134–1.890) | 0.003 |
Unknown | 1.296 (0.995–1.688) | 0.055 | 1.182 (0.904–1.545) | 0.221 |
T stage | ||||
T4a | 1 | 1 | ||
T4b | 1.543 (1.344–1.772) | < 0.001 | 1.193 (1.031–1.381) | 0.018 |
T4, NOS | 1.219 (1.079–1.378) | 0.002 | 1.103 (0.962–1.265) | 0.159 |
N stage | ||||
N0 | 1 | 1 | ||
N1 | 0.861 (0.763–0.972) | 0.015 | 1.116 (0.980–1.271) | 0.098 |
N2 | 0.834 (0.681–1.022) | 0.08 | 1.084 (0.879–1.337) | 0.452 |
N3 | 1.136 (0.875–1.476) | 0.339 | 1.717 (1.310–2.250) | < 0.001 |
N1–3, NOS | 1.071 (0.947–1.212) | 0.274 | 1.166 (1.024–1.328) | 0.021 |
Radiotherapy | ||||
No/unknown | 1 | 1 | ||
Yes | 0.433 (0.391–0.480) | < 0.001 | 0.573 (0.508–0.646) | < 0.001 |
Chemotherapy | ||||
No/unknown | 1 | 1 | ||
Yes | 0.368 (0.332–0.408) | < 0.001 | 0.497 (0.439–0.562) | < 0.001 |