Table 4 The optimal cut-off values, sensitivity, specificity, PPV, NPV, and AUC for TEG parameters and laboratory parameters (distinguish disease stages III/IV from I/II in CRC patients)

TEG parameters

 K (min)

1.7

73.1%

58.2%

52.9%

77.9%

0.712

0.661–0.763

< 0.001

 α-Angle (deg)

67.2

71.9%

60.8%

56.4%

75.4%

0.713

0.661–0.764

< 0.001

 MA (mm)

66.0

54.4%

78.0%

63.5%

70.8%

0.722

0.670–0.773

< 0.001

Laboratory parameters

 Hb (g/L)

122.5

62.5%

69.8%

58.8%

72.4%

0.677

0.621–0.731

< 0.001

 PLT (× 10⁹/L)

221.5

63.1%

57.3%

51.3%

68.9%

0.607

0.549–0.665

< 0.001

 PT (s)

12.5

32.5%

81.3%

55.3%

63.1%

0.578

0.520–0.636

0.009

 Fg (g/L)

4.4

54.4%

72.4%

58.3%

69.3%

0.620

0.561–0.678

< 0.001

 D-dimer (μg/L)

153

60.0%

60.9%

52.2%

68.5%

0.607

0.549–0.664

< 0.001

 CEA (μg/L)

4.5

55.6%

79.3%

62.7%

71.0%

0.707

0.653–0.761

< 0.001

 CA19-9 (U/mL)

22.1

43.1%

84.8%

62.7%

67.1%

0.662

0.605–0.719

< 0.001