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Table 2 The optimal cut-off values, sensitivity, specificity, PPV, NPV, and AUC for TEG parameters and laboratory parameters (distinguish CRC from HC + BA after propensity score matching)

From: Thromboelastography (TEG) parameters as potential predictors of malignancy and tumor progression in colorectal cancer

Variable

Cutoff

Sensitivity

Specificity

PPV

NPV

AUC

95% CI

P

TEG parameters

 R (min)

5.3

22.1%

94.3%

75.0%

54.7%

0.586

0.519–0.652

0.013

 K (min)

1.8

55.0%

77.9%

62.4%

65.9%

0.693

0.631–0.755

< 0.001

 α-Angle (deg)

67.4

45.0%

87.9%

78.8%

61.5%

0.687

0.625–0.749

< 0.001

 MA (mm)

60.0

78.6%

50.0%

61.1%

70.0%

0.700

0.639–0.760

< 0.001

Laboratory parameters

 Hb (g/L)

128.5

58.3%

78.4%

72.6%

65.3%

0.745

0.688–0.802

< 0.001

 PLT (× 109/L)

245.5

43.2%

80.7%

69.0%

58.5%

0.618

0.551–0.684

< 0.001

 PT (s)

11.6

70.5%

59.3%

64.1%

66.9%

0.670

0.606–0.734

< 0.001

 Fg (g/L)

4.2

46.8%

80.7%

70.8%

59.7%

0.638

0.572–0.704

< 0.001

 D-dimer (μg/L)

198.0

37.4%

91.7%

82.5%

59.4%

0.648

0.583–0.713

< 0.001

 CEA (μg/L)

2.4

58.0%

79.2%

76.2%

65.7%

0.726

0.666–0.787

< 0.001

 CA19-9 (U/mL)

13.5

37.0%

88.3%

78.5%

65.7%

0.633

0.566–0.700

< 0.001

  1. Abbreviations: PPV Positive predictive value, NPV Negative predictive value, AUC Area under the curve, Hb Hemoglobin, PLT Platelet, Fg Fibrinogen, PT Prothrombin time, CEA Carcinoma embryonic antigen, CA19-9 Carbohydrate antigen 19–9