Table 1 Characteristics of healthy controls (HC), benign adenoma (BA) patients, and colorectal cancer (CRC) patients

No. of cases

115

/

43

/

387

/

/

140

140

/

Age (years)

59.0 (50.0, 65.0)

0.077^*

62.0 (55.0, 69.0)

0.206^*

65.0 (59.0, 72.0)

< 0.001^*

< 0.001^*

62 (55.68)

61 (52.67)

0.277^{^}

Sex (male) (n, %)

53 (46.1)

0.828^{^}

24 (55.8)

1.000^{^}

232 (59.9)

0.025^{^}

0.031^{^}

77 (55.0)

76 (54.3)

0.904^{^}

Life style

 Smoking (n, %)

10 (8.7)

0.513^{^}

7 (16.3)

1.000^{^}

80 (20.7)

0.010^{^}

0.012^{^}

17 (12.1)

19 (13.6)

0.721^{^}

 Drinking (n, %)

10 (8.7)

0.989^{^}

6 (14.0)

1.000^{^}

67 (17.3)

0.073^{^}

0.076^{^}

16 (11.4)

19 (13.6)

0.588^{^}

Medical history

 Hypertension (n, %)

/

/

19 (44.2)

/

146 (37.7)

/

0.409^{^}

19 (13.6)

16 (11.4)

0.588^{^}

 Hyperlipidemia (n, %)

/

/

12 (27.9)

/

49 (12.7)

/

0.007^{^}

12 (8.6)

7 (5.0)

0.235^{^}

 Diabetes (n, %)

/

/

6 (14.0)

/

48 (12.4)

/

0.771^{^}

6 (4.3)

6 (4.3)

1.000^{^}

 Coronary heart disease (n, %)

/

/

0 (0.0)

/

10 (2.6)

/

0.608^{^}

0 (0)

0 (0)

/

Laboratory parameters

 Hb (g/L)

141.0 (132.0, 150.0)

0.032^*

133.0 (124.0, 145.0)

0.007^*

126.0 (108.0, 137.0)

< 0.001^*

< 0.001^*

139.5 (130.0, 149.0)

125.0 (107.5, 136.0)

< 0.001^#

 PLT (× 10⁹/L)

209.5 (190.0, 237.0)

0.932^*

206.5 (153.0, 236.0)

0.022^*

224.0 (183.0, 272.0)

0.054^*

0.004^*

208.5 (181.0, 236.0)

229.0 (187.0, 276.5)

0.001^#

 PT (s)

11.4 (11.1, 11.9)

1.000^*

11.5 (11.1, 11.9)

0.052^*

11.8 (11.3, 12.4)

< 0.001^*

< 0.001^*

11.4 (11.1, 11.9)

12.0 (11.4, 12.6)

< 0.001^#

 APTT (s)

31.4 (29.5, 32.9)

1.000^*

30.6 (28.7, 32.8)

0.731^*

30.3 (28.6, 32.3)

0.002^*

0.003^*

31.3 (29.1 32.9)

30.2 (29.0 32.3)

0.051^#

 TT (s)

14.4 (13.7, 15.0)

1.000^*

14.9 (13.9, 15.4)

1.000^*

14.4 (13.5, 15.3)

1.000^*

0.420^*

14.5 (13.7, 15.1)

14.5 (13.8, 15.3)

0.679^#

 Fg (g/L)

3.5 (3.1, 4.0)

1.000^*

3.7 (3.1, 4.1)

0.026^*

4.1 (3.4, 5.0)

< 0.001^*

< 0.001^*

3.6 (3.2, 4.1)

4.1 (3.3, 4.7)

< 0.001^#

 D-dimer (μg/L)

90.0 (59.0, 131.0)

0.045^*

120.0 (70.0, 180.0)

0.121^*

148.0 (89.0, 315.0)

< 0.001^*

< 0.001^*

94.5 (60.5, 137.5)

131.0 (85.0, 289.0)

< 0.001^#

 CEA (μg/L)

1.4 (0.9, 2.3)

0.662^*

1.7 (1.3, 2.7)

0.023^*

3.0 (1.6, 6.3)

< 0.001^*

< 0.001^*

1.5 (0.9, 2.3)

2.7 (1.4, 5.3)

< 0.001^#

 CA19-9 (U/mL)

5.9 (4.0, 10.7)

1.000^*

7.2 (5.0, 10.9)

0.126^*

10.5 (5.2, 23.8)

< 0.001^*

< 0.001^*

6.4 (4.3, 10.9)

9.0 (5.0, 19.6)

< 0.001^#

TEG parameters

 R (min)

6.7 (5.8, 7.7)

1.000^*

6.9 (6.1, 7.5)

0.051^*

6.3 (5.5, 7.1)

0.0370^*

0.006^*

6.7 (5.8, 7.7)

6.2 (5.7, 7.2)

0.013^#

 K (min)

1.9 (1.8, 2.2)

1.000^*

1.9 (1.7, 2.2)

< 0.001^*

1.6 (1.3, 1.9)

< 0.001^*

< 0.001^*

1.9 (1.8, 2.2)

1.7 (1.4, 2.0)

< 0.001^#

 α-Angle (deg)

63.8 (61.1, 66.2)

1.000^*

63.7 (61.5, 66.0)

< 0.001^*

67.4 (63.9, 70.6)

< 0.001^*

< 0.001^*

63.8 (61.2, 66.2)

66.9 (62.9, 70.2)

< 0.001^#

 MA (mm)

59.8 (56.9, 62.9)

1.000^*

60.8 (57.1, 63.0)

< 0.001^*

63.5 (60.4, 67.3)

< 0.001^*

< 0.001^*

60.2 (56.9, 63.0)

62.9 (60.3, 66.2)

< 0.001^#