From: Implication of perineural invasion in patients with stage II gastric cancer
Characteristics | Univariate | Â | Multivariate | Â |
---|---|---|---|---|
HR (95%CI) | p value | HR (95%CI) | p value | |
Gender (Male) | 1.45(0.82–2.55) | 0.198 |  |  |
Age (≥ 60 years) | 1.28(0.78–2.09) | 0.333 |  |  |
CEA (> 5 ng/ml) | 2.01(1.13–3.59) | 0.018 | 2.34(1.30 – 4.21) | 0.005 |
PNI (presence) | 1.7(1.04–2.77) | 0.034 | 1.70(1.04 – 2.8) | 0.035 |
Vascular invasion (Presence) | 1.16(0.66–2.05) | 0.604 |  |  |
Location (Ref: Lower) | ||||
 Middle | 2.86(1.54–5.31) |  < 0.001 | 3.26(1.73 – 6.14) |  < 0.001 |
 Upper | 0.96(0.47–1.99) | 0.916 | 0.96(0.46—1.99) | 0.904 |
 EGJ | 1.48(0.73–2.99) | 0.273 | 1.57(0.77—3.18) | 0.211 |
Tumor diameter (> 3 cm) | 0.73(0.45–1.18) | 0.200 |  |  |
Type of gastrectomy (Total) | 1.2(0.74–1.95) | 0.460 |  |  |
Adjuvant chemotherapy (Yes) | 0.6(0.36–1) | 0.048 | 0.52(0.31—0.86) | 0.011 |
Differentiation type (Poorly differentiated) | 1.11(0.62–1.98) | 0.727 |  |  |
Lauren classification (Ref: Intestinal) | ||||
 Diffuse | 1.29(0.71–2.36) | 0.402 |  |  |
 Mix | 1.1(0.55–2.19) | 0.781 |  |  |
 Others | 0.39(0.1–1.45) | 0.159 |  |  |
T Stage (T3/T4a) | 1.66(0.76–3.65) | 0.205 |  |  |
Lymph node metastasis (presence) | 1.33(0.81–2.16) | 0.258 |  |  |