From: Implication of perineural invasion in patients with stage II gastric cancer
Characteristics | Univariate | Â | Multivariate | Â |
---|---|---|---|---|
HR (95%CI) | p value | HR (95%CI) | p value | |
Gender (Male) | 1.41(0.77–2.57) | 0.267 |  |  |
Age (≥ 60 years) | 1.44(0.84–2.46) | 0.180 |  |  |
CEA (> 5 ng/ml) | 1.93(1.04–3.59) | 0.037 | 2.20(1.17—4.17) | 0.015 |
PNI (Presence) | 1.85(1.1–3.13) | 0.021 | 1.76(1.02 – 3.06) | 0.044 |
Vascular invasion (Presence) | 1.32(0.73–2.4) | 0.352 |  |  |
Location (Ref: Lower) | ||||
 Middle | 2.87(1.48–5.53) | 0.002 | 3.19(1.62 – 6.26) |  < 0.001 |
 Upper | 1.04(0.48–2.25) | 0.918 | 0.97(0.44—2.12) | 0.931 |
 EGJ | 1.59(0.76–3.35) | 0.221 | 1.58(0.75—3.33) | 0.233 |
Tumor diameter (> 3 cm) | 0.75(0.45–1.27) | 0.290 |  |  |
Type of gastrectomy (Total) | 1.20(0.72–2.03) | 0.482 |  |  |
Adjuvant chemotherapy (Yes) | 0.59(0.35–1.01) | 0.055 | 0.51(0.30—0.88) | 0.016 |
Differentiation type (Poorly differentiated) | 1.25(0.66–2.37) | 0.490 |  |  |
Lauren classification (Ref: Intestinal) | ||||
 Diffuse | 1.4(0.73–2.68) | 0.316 |  |  |
 Mix | 1.15(0.55–2.41) | 0.718 |  |  |
 Others | 0.5(0.13–1.91) | 0.309 |  |  |
T Stage (T3/T4a) | 2.33(0.93–5.83) | 0.072 | 1.55(0.59 – 4.03) | 0.371 |
Lymph node metastasis (Presence) | 1.3(0.77–2.19) | 0.329 |  |  |