Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer

Table 1 Regulation of HBP in lung cancer

Genes	Targets/pathways	Function	In vitro/in vivo	Reference
GFAT1	TAB1/MAPK	Autophagy↑cell survival↑	In vitro and in vivo	[12]
	EGFR	Cell survival↑	In vitro	[33]
	PD-L1	Tumor immunity↓	In vitro	[34]
GFPT1/2	KRAS	Senescence↑cell growth↑	In vitro and in vivo	[29, 35]
GFPT1/2	SIRT6/NF-κB	Cell migration and invasion↑	In vitro	[36]
GNPNAT1	p53	Immune infiltration↓	In vitro	[37]
PGM3	KRAS/LKB1	Cell proliferation↑	In vitro and in vivo	[38]
UAP1	…	Cell proliferation↑	In vitro	[39]
OGT	SAM68	Cell migration and invasion↑	In vitro	[40]
	LSD2	Cell proliferation↑	In vitro	[41]
	PKM2	Cell proliferation and differentiation↑	In vitro	[42]
	STAT3	Migration and invasion↑	In vitro	[43]
OGA	…	…	…	…

ISSN: 1477-7819