Fig. 2
From: Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
The molecular mechanism of HBP involved in lung cancer. Several small molecular compounds (DON, Azaserinethat, FR054, OSMI-1) target HBP enzymes are illustrated. Glc-6P, glucose-6-phosphate; Fruc-6P, fructose-6-phosphate; GPI, glucose-6-phosphate isomerase; GFPT1 or GFAT, glutamine-fructose 6-phosphate aminotransferase; GlcN-6P, glucosamine-6-phosphate; GNA1, d-glucosamine-6-phosphate N-Acetyltransferase; GlcNAc-6P, N-acetylglucosamine-6-phosphate; GlcNAc-1P, N-acetyl-1-phosphate glucosamine