Table 3 Missense variants in CYP4B1 associated with susceptibility of LC
SNP ID | Model | Genotype | control | case | Overall analysis | |
|---|---|---|---|---|---|---|
OR (95% CI) | p-value | |||||
rs2297810 | Allele | G | 1035 (77.01%) | 1011 (75.79%) | 1 | |
A | 309 (22.99%) | 323 (24.21%) | 1.07 (0.9-1.28) | 0.457 | ||
Codominant | GG | 405 (60.4%) | 370 (55.4%) | 1 | ||
AA | 43 (6.4%) | 25 (3.7%) | 0.62 (0.37-1.05) | 0.074 | ||
GA | 223 (33.2%) | 273 (40.9%) | 1.35 (1.08-1.69) | 0.010 | ||
Dominant | GG | 405 (60.4%) | 370 (55.4%) | 1 | ||
GA-AA | 266 (39.6%) | 298 (44.6%) | 1.22 (0.98-1.52) | 0.071 | ||
Overdominant | GG-AA | 448 (66.8%) | 395 (59.1%) | 1 | ||
GA | 223 (33.2%) | 273 (40.9%) | 1.39 (1.11-1.73) | 0.004 | ||
Log-additive | --- | --- | --- | 1.06 (0.89-1.27) | 0.510 | |
rs4646491 | Allele | C | 1035 (77.01%) | 1024 (76.76%) | 1 | |
TT | 309 (22.99%) | 310 (23.24%) | 1.01 (0.85-1.21) | 0.879 | ||
Codominant | CC | 405 (60.4%) | 382 (57.2%) | 1 | ||
TT | 43 (6.4%) | 24 (3.6%) | 0.98 (0.34-0.98) | 0.056 | ||
CT | 223 (33.2%) | 262 (39.2%) | 1.26 (1.00-1.58) | 0.051 | ||
Dominant | CC | 405 (60.4%) | 382 (57.2%) | 1 | ||
CT-TT | 266 (39.6%) | 286 (42.8%) | 1.14 (0.91-1.41) | 0.250 | ||
Overdominant | CC-TT | 448 (66.8%) | 406 (60.8%) | 1 | ||
CT | 223 (33.2%) | 262 (39.2%) | 1.30 (1.04-1.62) | 0.023 | ||
Log-additive | --- | --- | --- | 1.01 (0.84-1.21) | 0.950 | |
rs2297809 | Allele | C | 1033 (77.09%) | 1023 (76.92%) | 1 | |
T | 307 (22.91%) | 307 (23.08%) | 1.01 (0.84-1.21) | 0.916 | ||
Codominant | CC | 405 (60.5%) | 382 (57.4%) | 1 | ||
TT | 43 (6.4%) | 23 (3.5%) | 1.05 (0.83-1.14) | 0.059 | ||
CT | 221 (33%) | 261 (39.2%) | 1.26 (1.01-1.59) | 0.046 | ||
Dominant | CC | 405 (60.5%) | 382 (57.4%) | 1 | ||
TC-TT | 264 (39.5%) | 284 (42.6%) | 1.14 (0.91-1.41) | 0.250 | ||
Overdominant | CC-TT | 448 (67%) | 405 (60.8%) | 1 | ||
CT | 221 (33%) | 261 (39.2%) | 1.31 (1.04-1.63) | 0.020 | ||
Log-additive | --- | --- | --- | 1.00 (0.83-1.20) | 0.990 | |