Missense variants in CYP4B1 associated with increased risk of lung cancer among Chinese Han population

Table 2 The basic information and HWE about the candidate SNPs of CYP4B1

SNP ID	Function	Amino acid	Chr: Position	Alleles (A/B)	MAF		MAF in different populations				HWE (P Value)	Haploreg 4.1
SNP ID	Function	Amino acid	Chr: Position	Alleles (A/B)	Cases	Controls	CHB	CHS	AFR	EUR	HWE (P Value)	Haploreg 4.1
rs2297810	missense	M (Met) > I (Ile)	1: 46815187	A/G	0.242	0.230	0.335	0.333	0.461	0.131	0.103	SiPhy cons; Enhancer histone marks; Motifs changed; GRASP eQTL hits; Selected eQTL hits
rs4646491	missense	R (Arg) > S (Ser)	1: 46815212	T/C	0.232	0.230	0.330	0.305	0.039	0.130	0.103	SiPhy cons; Enhancer histone marks; Motifs changed; GRASP eQTL hits; Selected eQTL hits
rs2297809	missense	R (Arg) > C (Cys)	1: 46817100	T/C	0.231	0.229	0.330	0.300	0.130	0.126	0.100	SiPhy cons; Motifs changed; Selected eQTL hits

Met Methionine, Ile Isoleucine, Arg Arginine, Ser Serine, Cys Cystine, A minor allele, B wild-type allele, HWE Hardy–Weinberg equilibrium, SNP Single nucleotide polymorphisms, MAF Minor allele frequency, CHB Han Chinese in Beijing, China, CHS Han Chinese in Shanghai, China, EUR European, AFR African
P > 0.05 indicates that the genotypes were in Hard-weinberg Equilibrium

ISSN: 1477-7819