Table 3 Subgroup analysis of grade 3 or higher adverse events

Adverse events

4

1.22

1.05–1.42

0.01

63%

0.04

Neutropenia

7

1.03

0.89–1.20

0.65

65%

0.009

Febrile neutropenia

4

1.30

0.89–1.90

0.18

0

0.84

Leukopenia

6

1.14

0.81–1.61

0.46

57%

0.04

Diarrhea

8

1.71

1.49–1.97

 < 0.001

0

0.78

Fatigue

6

1.54

1.20–1.99

 < 0.001

0

0.49

Rash

5

26.60

4.93–143.62

 < 0.001

81%

 < 0.001

Skin reactions

4

44.52

18.49–107.20

 < 0.001

24%

0.27

Vomiting

4

1.38

0.81–1.37

0.23

43%

0.15

Thrombocytopenia

4

1.18

0.80–1.76

0.41

0

0.48

Hemoglobin

4

2.43

1.44–4.11

 < 0.001

0

0.68

Neurologic toxicities

4

0.82

0.63–1.08

0.16

36%

0.19

Hypomagnesemia

4

13.10

5.28–32.49

 < 0.001

0

0.40

Stomatitis

4

2.90

1.76–4.78

 < 0.001

0

0.43

Cardiac events

4

29.62

2.87–305.77

0.004

73%

0.01

Infusion-related reaction

5

2.32

1.04–5.17

0.04

31%

0.22