Outcomes | No. of studies | RR | 95% CI | P | Heterogeneity | |
---|---|---|---|---|---|---|
I2 | P | |||||
ORR | 8 | 1.24 | 1.13, 1.37 |  < 0.001 | 52% | 0.03 |
RAS/KRAS wild type | 8 | 1.20 | 1.02, 1.41 | 0.03 | 81% |  < 0.001 |
KRAS mutant | 4 | 0.99 | 0.78, 1.25 | 0.94 | 64% | 0.04 |
Cetuximab | 6 | 1.28 | 1.13, 1.45 |  < 0.001 | 58% | 0.04 |
Panitumumab | 2 | 1.18 | 0.98, 1.42 | 0.08 | 55% | 0.11 |
R0 resection | 8 | 1.63 | 1.27, 2.09 |  < 0.001 | 0 | 0.48 |
RAS/KRAS wild type | 8 | 1.60 | 1.17, 2.20 | 0.003 | 23% | 0.25 |
KRAS mutant | 2 | 2.90 | 0.46, 18.54 | 0.26 | 18% | 0.27 |
Cetuximab | 6 | 1.69 | 1.26, 2.28 |  < 0.001 | 0 | 0.50 |
Panitumumab | 2 | 1.66 | 0.80, 3.43 | 0.18 | 48% | 0.17 |