Fig. 8

Cell communication analysis and WGCNA analysis of LUAD. A Network plot showing the number of ligand-receptor interactions detected in LUAD. B Circos plots showing top 100 highly expressed ligand-receptor interactions (upper panel). Circos plot showing significantly different ligand-receptor interactions between cells high and low P2RY6 expression (lower panel). C Clustering dendrograms of genes. D Gene module–trait associations. Each row corresponds to an ME. The corresponding correlation and p-value are shown in the cells. The cells are color coded by the correlation according to the color legend. E Significantly enriched KEGG pathway in model blue