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Table 4 Correlation analysis between ODAD2- rs7893462 and clinical parameters in Guangxi HBV-related HCC patients

From: Outer dynein arm docking complex subunit 2 polymorphism rs7893462 modulates hepatocellular carcinoma susceptibility and can serve as an overall survival biomarker for hepatitis B virus-related hepatocellular carcinoma after hepatectomy: a cohort study with a long-term follow-up

Variables

GG (n = 144)

AA + AG (n = 324)

OR (95%CI)

P

AG (n = 212)

AA + GG (n = 256)

OR (95%CI)

P

Age (years)

 ≤ 60

125

289

1

 

190

224

1

 

  > 60

19

35

0.797 (0.439–1.447)

0.46

22

32

1.234 (0.693–2.195)

0.475

Gender

 Male

126

288

1

 

194

220

1

 

 Female

18

36

0.875 (0.479–1.600)

0.66

18

36

1.764 (0.970–3.207)

0.063

Ethnicity

 Han

94

202

1

 

133

163

1

 

 Minority

50

122

1.135 (0.753–1.711)

0.54

79

93

0.961 (0.659–1.401)

0.834

BMI

 ≤ 25

118

251

1

 

167

202

1

 

 > 25

26

73

1.320 (0.802–2.172)

0.28

45

54

0.992 (0.635–1.549)

0.972

Smoking status

 None

96

212

1

 

133

175

1

 

 Ever

48

112

1.057 (0.698–1.601)

0.8

79

81

0.779 (0.531–1.143)

0.202

Drinking status

 None

91

193

1

 

122

162

1

 

 Ever

53

131

1.165 (0.777–1.747)

0.46

90

94

0.787 (0.542–1.142)

0.206

Child–Pugha

 A

113

268

1

 

169

212

1

 

 B

20

38

0.801 (0.447–1.437)

0.46

28

30

0.854 (0.491–1.485)

0.576

Cirrhosisb

 No

13

43

1

 

26

30

1

 

 Yes

131

280

0.646 (0.336–1.243)

0.19

185

226

1.059 (0.605–1.853)

0.842

Radical resectionc

 Yes

89

172

1

 

106

155

1

 

 No

55

143

1.345 (0.899–2.013)

0.15

100

98

0.670 (0.462–0.973)

0.035

Pathological diagnosisd

 Well differentiated

11

14

1

 

11

14

1

 

 Moderately differentiated

106

255

1.890 (0.831–4.298)

0.13

165

196

0.933 (0.413–2.111)

0.868

 Poorly differentiated

3

8

2.095 (0.447–9.814)

0.35

7

4

0.449 (0.104–1.934)

0.283

Tumor size

 ≤ 5 cm

62

127

1

 

77

112

1

 

 > 5 cm

82

197

1.173 (0.788–1.747)

0.43

135

144

0.733 (0.505–1.065)

0.103

Tumor number

 Single

109

237

1

 

156

190

1

 

 Multiple

35

87

1.143 (0.727–1.799)

0.56

56

66

0.968 (0.639–1.464)

0.876

BCLC

 A

90

187

1

 

115

162

1

 

 B

22

52

1.138 (0.651–1.988)

0.65

34

40

0.835 (0.499–1.399)

0.494

 C

32

85

1.278 (0.793–2.062)

0.31

63

54

0.608 (0.394–0.940)

0.025

Portal vein tumor thrombuse

 No

123

260

1

 

166

217

1

 

 Yes

21

63

1.419 (0.828–2.432)

0.2

45

39

0.663 (0.413–1.065)

0.089

Serum AFPf

 AFP ≤ 400 (ng/mL)

75

166

1

 

108

133

1

 

 AFP > 400 (ng/mL)

57

136

1.078 (0.714–1.628)

0.72

86

107

1.010 (0.690–1.479)

0.958

  1. Abbreviation: HBV hepatitis B virus, HCC hepatocellular carcinoma, HR hazard ratio, CI confidence interval, MST median survival time, BCLC Barcelona Clinic Liver Cancer, AFP α-fetoprotein, NA not available, BMI body mass index
  2. aInformation of Child–Pugh was unavailable in 29 patients
  3. bInformation of cirrhosis was unavailable in 1 patient
  4. cInformation of radical resection was unavailable in 9 patients
  5. dInformation of pathological diagnosis was unavailable in 71 patients
  6. eInformation of PVTT was unavailable in 1 patient
  7. fInformation of AFP was unavailable in 34 patients
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World Journal of Surgical Oncology

ISSN: 1477-7819

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