Outer dynein arm docking complex subunit 2 polymorphism rs7893462 modulates hepatocellular carcinoma susceptibility and can serve as an overall survival biomarker for hepatitis B virus-related hepatocellular carcinoma after hepatectomy: a cohort study with a long-term follow-up

Table 1 Survival analysis of ODAD2- rs7893462 in Guangxi HBV-related HCC patients

Genotype	Patients(n = 468)	MST (months)	Crude HR (95% CI)	Crude P	Adjusted HR (95% CI)	Adjusted P^ɠ
rs7893462
AA	112	95	1		1
AG	212	39	1.916 (1.339–2.743)	< 0.0001	1.806 (1.240–2.630)	0.002
GG	144	81	1.059 (0.707–1.585)	0.781	0.895 (0.586–1.368)	0.61
rs7893462
AG	212	39	1		1
AA	112	95	0.522 (0.365–0.747)	0.0004	0.554 (0.380–0.807)	0.002
GG	144	81	0.553 (0.403–0.7577)	0.0002	0.496 (0.352–0.698)	< 0.0001
AA + GG	256	93	0.540 (0.413–0.705)	< 0.0001	0.519 (0.389–0.693)	< 0.0001
rs7893462
AA	112	95	1		1
AG + GG	356	48	1.515 (1.075–2.136)	0.018	1.351 (0.945–1.932)	0.099
rs7893462
GG	144	81	1		1
AA + AG	324	45	1.471 (1.088–1.988)	0.012	1.652 (1.194–2.286)	0.002

Abbreviation: HBV hepatitis B virus, HCC hepatocellular carcinoma, HR hazard ratio, CI confidence interval, MST median survival time, OS overall survival, BCLC Barcelona Clinic Liver Cancer, AFP α-fetoprotein, NA not available, ODAD2 outer dynein arm docking complex subunit 2
^ɠOS adjusted for tumor number, tumor size, portal vein tumor thrombus, radical resection, BCLC, and AFP in multivariate Cox proportional risk regression model

ISSN: 1477-7819