Variable | metachronous PM | Univariable Cox regression analysis | ||
---|---|---|---|---|
n (%) | HR | 95% CI | p-value | |
Age (years) | 278 (5.1) | 0.991 | 0.979–1.003 | 0.146 |
Sex | 0.450 | |||
Male | 156 (4.9) | Ref | Ref | |
Female | 122 (5.4) | 1.096 | 0.864–1.388 | |
Primary tumor location | 0.189 | |||
Right colon | 107 (6.4) | 1.286 | 0.981–1.685 | |
Left colon | 106 (5.2) | Ref | Ref | |
Rectum | 65 (3.8) | 1.155 | 0.846–1.576 | |
Tumor differentiation | < 0.001 | |||
Good/moderate | 206 (4.7) | Ref | Ref | |
Poor/undifferentiated | 38 (8.7) | 2.173 | 1.537–3.071 | |
Tumor stage | < 0.001 | |||
T0–2 | 20 (1.0) | Ref | Ref | |
T3 | 152 (5.5) | 5.852 | 3.674–9.328 | |
T4 | 106 (17.0) | 18.822 | 11.672–30.354 | |
Nodal stage | < 0.001 | |||
N0 | 51 (2.0) | Ref | Ref | |
N1 | 118 (6.5) | 3.339 | 2.405–4.638 | |
N2 | 107 (11.0) | 6.6412 | 4.593–8.952 | |
Tumor histology | < 0.001 | |||
Adenocarcinoma | 233 (4.7) | Ref | Ref | |
Mucinous adenocarcinoma | 34 (8.2) | 1.786 | 1.247–2.560 | |
Signet ring cell carcinoma | 11 (24.4) | 6.277 | 3.428–11.494 | |
Weight category | 0.376 | |||
1. (BMI < 18.5); underweight | 1 (1.1) | 0.215 | 0.030–1.537 | |
2. (BMI 18.5–25); normal weight | 107 (5.4) | Ref | Ref | |
3. (BMI 25–30); overweight | 117 (5.2) | 0.913 | 0.703–1.187 | |
4. (BMI > 30); obesity | 53 (4.8) | 0.857 | 0.617–1.191 | |
Synchronous systemic metastasis | < 0.001 | |||
Yes | 68 (15.9) | 5.374 | 4.083–7.073 | |
No | 210 (4.2) | Ref | Ref |