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Table 3 Multivariable Cox regression analyses for the development of metachronous peritoneal metastases after curative primary tumor resection

From: The impact of body weight on the development of peritoneal metastases in colorectal cancer patients: results from a nationwide cohort study

Variable

Crude rate metachronous PM after median FU of 16.5 months

Multivariable Cox regression analysis*

n (%)

HR

95% CI

p-value

Weight category

 1. (BMI < 18.5); underweight

1 (1.1)

0.162

0.023–1.159

0.125

 2. (BMI 18.5–25); normal weight

107 (5.4)

Ref

Ref

Ref

 3. (BMI 25–30); overweight

117 (5.2)

1.065

0.819–1.386

0.638

 4. (BMI ≥ 30); obesity

53 (4.8)

1.017

0.730–1.159

0.919

Tumor differentiation

 Good/moderate

206 (4.7)

Ref

Ref

Ref

 Poor/undifferentiated

38 (8.7)

1.232

0.862–1.761

0.252

Tumor stage

 T0–2

20 (1.0)

Ref

Ref

Ref

 T3

152 (5.5)

4.003

2.456–6.525

< 0.001

 T4

106 (17.0)

11.447

6.844–19.14

< 0.001

Nodal stage

 N0

51 (2.0)

Ref

Ref

Ref

 N1

118 (6.5)

2.038

1.456–2.852

< 0.001

 N2

107 (11.0)

2.836

1.898–4.045

< 0.001

Tumor histology

 Adenocarcinoma

233 (4.7)

Ref

Ref

Ref

 Mucinous adenocarcinoma

34 (8.2)

1.979

1.313–2.983

0.001

 Signet ring cell carcinoma

11 (24.4)

4.455

2.247–8.831

< 0.001

Synchronous systemic metastasis

 Yes

68 (15.9)

3.045

2.279–4.068

< 0.001

 No

210 (4.2)

Ref

Ref

Ref

  1. PM Peritoneal metastases, n Number, HR Hazard ratio, CI Confidence interval, BMI Body mass index (in kg/m2)
  2. *Missing data were excluded from the regression model