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Table 2 Comparison of clinical and histopathological parameters between groups

From: Predictive factors and repetition numbers for intraoperative additional resection of initially involved soft tissue resection margins in oral squamous cell carcinoma: a retrospective study

Variable

All patients (n = 197)

Without IAR (n = 153)

With IAR (n = 44)

p-value

Clinical preoperative parameters

 Tumor location (n)

  Tongue

61 (31.0%)

53 (34.6%)

8 (18.2%)

0.204

  Floor of mouth

52 (26.4%)

41 (26.8%)

11 (25.0%)

  Mandible

28 (14.2%)

19 (12.4%)

9 (20.5%)

  Maxilla

18 (9.1%)

11 (7.2%)

7 (15.9%)

  Cheek

19 (9.6%)

14 (9.2%)

5 (11.4%)

  Soft palate

18 (9.1%)

14 (9.2%)

4 (9.1%)

  Hard palate

1 (0.5%)

1 (0.7%)

0 (0.0%)

 Midline involvement (n)

  No

162 (82.2%)

124 (81.0%)

38 (86.4%)

0.416

  Yes

35 (17.8%)

29 (19.0%)

6 (13.6%)

 cT-status > 2 (n)

  No

147 (74.6%)

118 (77.1%)

29 (65.9%)

0.132

  Yes

50 (25.4%)

35 (22.9%)

15 (34.1%)

 Time SI-T (days) (median (IQR))

11.0 (10.0)

11.0 (10.0)

13.5 (13.0)

0.329

Clinical intraoperative parameters

 Bone resection (n)

  No

90 (45.7%)

75 (49.0%)

15 (34.1%)

0.080

  Yes

107 (54.3%)

78 (51.0%)

29 (65.9%)

 Monopolar instrument use (n)

  No

50 (25.4%)

42 (27.5%)

8 (18.2%)

0.213

  Yes

147 (74.6%)

111 (72.5%)

36 (81.8%)

 Reconstruction flap size (n)

  Small

137 (69.5%)

108 (70.6%)

29 (65.9%)

0.552

  Large

60 (30.5%)

45 (29.4%)

15 (34.1%)

Histopathological postoperative parameters

 pT-status > 2 (n)

  No

133 (67.5%)

110 (71.9%)

23 (52.3%)

0.014

  Yes

64 (32.5%)

43 (28.1%)

21 (47.7%)

 Grading > 2 (n)

  No

159 (80.7%)

123 (80.4%)

36 (81.8%)

0.833

  Yes

38 (19.3%)

30 (19.6%)

8 (18.2%)

 Vascular invasion (n)

  No

193 (98.0%)

150 (98.0%)

43 (97.7%)

1.000

  Yes

4 (2.0%)

3 (2.0%)

1 (2.3%)

 Lymphatic invasion (n)

  No

184 (93.4%)

146 (95.4%)

38 (86.4%)

0.033

  Yes

13 (6.6%)

7 (4.6%)

6 (13.6%)

  1. Data presented as numbers (with percentage) (tumor location, midline involvement, cT-status, bone resection, monopolar instrument use, reconstruction flap size, pT-status, grading, vascular invasion, lymphatic invasion) for categorical data and as median (with interquartile range) for metric data (time interval SI-T) separately for all patients and subdivided into patients without intraoperative additional resection (without IAR) and patients with intraoperative additional resection (with IAR); reconstruction flap size small: radial free forearm flap, scapula free flap, soleus perforator flap; reconstruction flap size large: anterolateral thigh flap, fibula free flap, latissimus dorsi flap; p-values corresponding to testing for differences between groups with chi-squared test (midline involvement, cT-status, bone resection, monopolar instrument use, reconstruction flap size, pT-status, grading, lymphatic invasion), Freeman Halton test (tumor location), Fisher’s exact test (vascular invasion), and Mann–Whitney test (time interval SI-T); significant p-values are bold
  2. Abbreviations: AR intraoperative additional resection, cT-status clinical T-status, SI-T staging imaging to therapy interval, pT-status histopathologic T-status
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World Journal of Surgical Oncology

ISSN: 1477-7819

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