Predictive factors and repetition numbers for intraoperative additional resection of initially involved soft tissue resection margins in oral squamous cell carcinoma: a retrospective study

Table 1 Study population

Variable	All patients (n = 197)	Without IAR (n = 153)	With IAR (n = 44)	p-value
*Sex* (n)
Male	107 (54.3%)	85 (55.6%)	22 (50.0%)	0.514
Female	90 (45.7%)	68 (44.4%)	22 (50.0%)	0.514
*Age* (years) (median (IQR))	63.0 (17.0)	64.0 (16.0)	61.5 (23.0)	0.581
*UICC stage* (n)
I	53 (26.9%)	44 (28.8%)	9 (20.5%)	0.123
II	36 (18.3%)	32 (20.9%)	4 (9.1%)
III	37 (18.8%)	28 (18.3%)	9 (20.5%)
IVa	58 (29.4%)	39 (25.5%)	19 (43.2%)
IVb	13 (6.6%)	10 (6.5%)	3 (6.8%)
IVc	0 (0.0%)	0 (0.0%)	0 (0.0%)
*Therapy* (n)
surgery	103 (52.3%)	89 (58.2%)	14 (31.8%)	0.008
surgery + RTX	66 (33.5%)	44 (28.8%)	22 (50.0%)
surgery + RCTX	28 (14.2%)	20 (13.1%)	8 (18.2%)
*Definite resection margin distance* (n)
< 5mm	70 (35.5%)	51 (33.3%)	19 (43.2%)	0.229
≥ 5mm	127 (64.5%)	102 (66.7%)	25 (56.8%)	0.229

Data presented as numbers (with percentage) (sex, UICC stage, therapy, definite resection margin distance) for categorical data and as median (with interquartile range) for metric data (age) separately for all patients and subdivided into patients without intraoperative additional resection (without IAR) and patients with intraoperative additional resection (with IAR); p-values corresponding to testing for differences between groups with chi-squared test (sex, therapy, definite resection margin distance), Freeman Halton test (UICC stage), and Mann Whitney test (age); significant p-values are bold
Abbreviations: IAR intraoperative additional resection, UICC Union for International Cancer Control, RTX radiotherapy, RCTX radiochemotherapy

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