Screening and identifying of biomarkers in early colorectal cancer and adenoma based on genome-wide methylation profiles

Table 7 Distribution of DNA methylation Index among six genes in colorectal cancers, adenomas and normal controls

	Colorectal cancer (N = 68)			Colorectal adenoma (N = 31)			Normal control (N = 49)			P value^a	P value^b
Gene	Mean ± SD	Median	Range	Mean ± SD	Median	Range	Mean ± SD	Median	Range	P value^a	P value^b
ZNF471	24.32 ± 19.91	20.20	0.00–77.69	22.69 ± 13.28	23.36	4.74–54.63	6.60 ± 2.17	6.91	0.00–11.93	< 0.001	< 0.001
SND1	58.16 ± 22.38	65.18	4.11–88.11	51.20 ± 23.84	52.30	3.83–81.59	5.42 ± 4.62	3.59	0.23–19.77	< 0.001	< 0.001
SPOCK1	41.70 ± 19.54	39.13	3.41–77.11	27.47 ± 20.49	27.04	2.78–75.50	5.32 ± 2.84	4.63	0.87–13.43	< 0.001	< 0.001
FBLIM1	56.94 ± 23.30	62.29	2.71–89.92	50.55 ± 24.49	56.11	5.03–76.27	7.15 ± 8.14	5.02	0.00–76.07	< 0.001	< 0.001
OTX1	57.27 ± 18.10	60.95	5.01–82.83	47.26 ± 24.44	54.29	3.10–78.97	9.02 ± 4.78	7.81	0.00–23.06	< 0.001	< 0.001

^a,bSummary statistics with a nonparametric Mann–Whitney test comparing colorectal cancers with normal control (a) and adenomas with normal control (b) for each gene

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