Fig. 6

Clustering analysis of differential CpGs methylation marker in colorectal cancer and adenoma tissues. A Unsupervised hierarchical clustering and heat map associated with the methylation profile of the colorectal cancer specimens. B Unsupervised hierarchical clustering and heat map associated with the methylation profile of the adenoma specimens. The relative methylation level is depicted according to the color scale. Red indicates hypermethylation; green indicates hypo-methylation. − 3, 0, and 3 are fold changes in the corresponding spectrum