From: Elderly patients with stage II gastric cancer do not benefit from adjuvant chemotherapy
Characteristic | Overall survival | Cancer-specific survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | p valuea | HR (95% CI) | p valuea | HR (95% CI) | p valuea | HR (95% CI) | p valuea | |
Age | ||||||||
Non-EGC | 1 | 1 | 1 | 1 | ||||
EGC | 3.77 (1.82 − 7.78) | < 0.001 | 3.38 (1.57–7.27) | 0.002 | 3.50 (1.54–7.93) | 0.003 | 3.74 (1.64–8.55) | 0.002 |
Gender | ||||||||
Male | 1 | 1 | ||||||
Female | 0.90 (0.49–1.66) | 0.739 | 0.77 (0.39–1.55) | 0.471 | ||||
BMI (kg/m2) | ||||||||
18.5–24 | 1 | 1 | 1 | |||||
< 18.5 | 2.25 (1.13–4.49) | 0.021 | 1.67 (0.81–3.45) | 0.165 | 1.87 (0.85–4.12) | 0.120 | ||
≥ 24 | 0.67 (0.29–1.51) | 0.331 | 0.70 (0.31–1.59) | 0.396 | 0.55 (0.21–1.42) | 0.215 | ||
CEA | ||||||||
Negative | 1 | 1 | 1 | 1 | ||||
Positive | 3.30 (1.84–5.91) | < 0.001 | 3.16 (1.74–5.74) | < 0.001 | 3.75 (1.99–7.07) | < 0.001 | 3.73 (1.96–7.11) | < 0.001 |
CA199 | ||||||||
Negative | 1 | 1 | ||||||
Positive | 1.58 (0.74 − 3.36) | 0.240 | 1.43 (0.6 − 3.4) | 0.422 | ||||
Location | ||||||||
Lower | 1 | 1 | ||||||
Upper | 0.77 (0.38–1.58) | 0.479 | 0.78 (0.36 − 1.71) | 0.541 | ||||
Middle | 1.36 (0.69 − 2.67) | 0.370 | 1.21 (0.57 − 2.6) | 0.616 | ||||
Overlapped | 1.23 (0.29–5.30) | 0.782 | 1.46 (0.33 − 6.38) | 0.617 | ||||
Lauren type | ||||||||
Intestinal | 1 | 1 | ||||||
Diffuse | 1.27 (0.66–2.47) | 0.477 | 1.72 (0.8–3.69) | 0.168 | ||||
Mixed | 1.19 (0.57–2.51) | 0.640 | 1.50 (0.64–3.54) | 0.354 | ||||
Grade | ||||||||
Well | 1 | 1 | ||||||
Moderately | 3.70 (0.49–27.9) | 0.205 | 2.54 (0.33–19.67) | 0.373 | ||||
Poorly and undifferentiated | 3.97 (0.54–29.1) | 0.175 | 3.43 (0.47–25.27) | 0.226 | ||||
T stage | ||||||||
T1-2 | 1 | 1 | 1 | |||||
T3-4 | 2.28 (0.82–6.35) | 0.114 | 1.41 (0.40–4.98) | 0.599 | 2.49 (0.77–8.06) | 0.129 | 1.48 (0.32–6.73) | 0.616 |
N stage | ||||||||
N0 | 1 | 1 | 1 | |||||
N1 | 0.94 (0.52–1.69) | 0.835 | 0.96 (0.51–1.8) | 0.887 | 0.87 (0.45–1.67) | 0.675 | 0.87 (0.43–1.75) | 0.691 |
N2 | 0.24 (0.03–1.73) | 0.156 | 0.33 (0.03–3.54) | 0.361 | 0.28 (0.04–2.07) | 0.213 | 0.42 (0.03–5.14) | 0.493 |
N3 | 0 (0-Inf) | 0.997 | 0 (0-Inf) | 0.997 | 0 (0-Inf) | 0.997 | 0 (0-Inf) | 0.997 |
Surgery | ||||||||
Open | 1 | 1 | ||||||
Laparoscope | 1.05 (0.58–1.87) | 0.879 | 0.97 (0.51–1.85) | 0.937 | ||||
Chemotherapy | ||||||||
No | 1 | 1 | ||||||
Yes | 1.18 (0.59–2.36) | 0.644 | 1.70 (0.71–4.06) | 0.231 |