Table 1 The clinicopathological characteristics in stage II elderly GC patients of local cohort and SEER cohort
From: Elderly patients with stage II gastric cancer do not benefit from adjuvant chemotherapy
Characteristic | Local cohort | SEER cohort | ||||
|---|---|---|---|---|---|---|
Non-EGC (N = 283) | EGC (N = 21) | p valuea | Non-EGC (N = 909) | EGC (N = 423) | p valuea | |
Gender | 0.211 | 0.001 | ||||
Male | 184 (65.0%) | 17 (81.0%) | 560 (61.6%) | 220 (52.0%) | ||
Female | 99 (35.0%) | 4 (19.0%) | 349 (38.4%) | 203 (48.0%) | ||
BMI (kg/m2) | < 0.001 | |||||
18.5–24 | 190 (67.1%) | 10 (47.6%) | ||||
< 18.5 | 26 (9.2%) | 9 (42.9%) | ||||
≥ 24 | 67 (23.7%) | 2 (9.5%) | ||||
CEA | 0.615 | |||||
Negative | 238 (84.1%) | 15 (71.4%) | ||||
Positive | 45 (15.9%) | 6 (28.6%) | ||||
CA199 | 0.015 | |||||
Negative | 257 (90.8%) | 15 (71.4%) | ||||
Positive | 26 (9.2%) | 6 (28.6%) | ||||
Location | 0.499 | 0.015 | ||||
Lower | 110 (38.9%) | 7 (33.3%) | 372 (40.9%) | 210 (49.6%) | ||
Upper | 93 (32.9%) | 10 (47.6%) | 47 (5.2%) | 13 (3.1%) | ||
Middle | 71 (25.1%) | 4 (19.0%) | 405 (44.6%) | 168 (39.7%) | ||
Overlapped | 9 (3.2%) | 0 (0%) | 85 (9.4%) | 32 (7.6%) | ||
Histology | < 0.001 | |||||
Adenocarcinoma | 666 (73.3%) | 383 (90.5%) | ||||
Signet ring cell carcinoma | 243 (26.7%) | 40 (9.5%) | ||||
Lauren type | 0.111 | |||||
Intestinal | 89 (31.4%) | 8 (38.1%) | ||||
Diffuse | 117 (41.3%) | 4 (19.0%) | ||||
Mixed | 77 (27.2%) | 9 (42.9%) | ||||
Grade | 0.502 | 0.017 | ||||
Well | 16 (5.7%) | 0 (0%) | 25 (2.8%) | 16 (3.8%) | ||
Moderately | 86 (30.4%) | 6 (28.6%) | 274 (30.1%) | 157 (37.1%) | ||
Poorly and undifferentiated | 181 (64.0%) | 15 (71.4%) | 610 (67.1%) | 250 (59.1%) | ||
T stage | 0.989 | 0.353 | ||||
T1-2 | 48 (17.0%) | 3 (14.3%) | 227 (25.0%) | 95 (22.5%) | ||
T3-4 | 235 (83.0%) | 18 (85.7%) | 682 (75.0%) | 328 (77.5%) | ||
N stage | 0.950 | 0.182 | ||||
N0 | 149 (52.7%) | 12 (57.1%) | 419 (46.1%) | 220 (52.0%) | ||
N1 | 110 (38.9%) | 7 (33.3%) | 370 (40.7%) | 155 (36.6%) | ||
N2 | 23 (8.1%) | 2 (9.5%) | 104 (11.4%) | 44 (10.4%) | ||
N3 | 1 (0.4%) | 0 (0%) | 16 (1.8%) | 4 (0.9%) | ||
Surgery | 0.163 | |||||
Open | 86 (30.4%) | 10 (47.6%) | ||||
Laparoscope | 197 (69.6%) | 11 (52.4%) | ||||
Chemotherapy | 0.064 | < 0.001 | ||||
No | 53 (18.7%) | 8 (38.1%) | 212 (23.3%) | 268 (63.4%) | ||
Yes | 230 (81.3%) | 13 (61.9%) | 697 (76.7%) | 155 (36.6%) | ||