Table 3 Clinical course after salvage surgery
Characteristics | Cytotoxic agent (n = 12) | TKI (n = 16) | ICI (n = 4) | All drugs (n = 32) |
|---|---|---|---|---|
Postoperative treatment | ||||
 Cytotoxic chemotherapy | 5 (42) | 1 (6) | 1 (25) | 7 (22) |
 Chemoradiotherapy/radiation therapy | 0 | 3 (19) | 0 | 3 (9) |
 TKI therapy | 1 (8) | 7 (44) | 0 | 8 (25) |
 Radiation therapy to the mediastinum | 2 (17) | 1 (6) | 0 | 3 (9) |
Recurrence after salvage surgery | 8 (67) | 13 (81) | 2 (50) | 23 (72) |
Initial metastatic/progressive site after surgery | ||||
 Locoregional | 0 | 4 (32) | 0 | 4 (13) |
 Distant | 8 (67) | 9 (56) | 2 (50) | 19 (59) |
Treatment for recurrence after salvage surgery | ||||
 Systemic treatment | ||||
  Cytotoxic chemotherapy | 2 (17) | 2 (13) | 2 (50) | 6 (19) |
  Cytotoxic chemotherapy plus ICI therapy | 1 (8) | 0 | 0 | 1 (3) |
  ICI therapy | 2 (17) | 0 | 0 | 2 (6) |
  TKI therapy | 1 (8) | 5 (31) | 0 | 6 (19) |
  TKI plus cytotoxic chemotherapy | 1 (8) | 2 (13) | 0 | 3 (9) |
 Local treatment | ||||
  Radiation therapy | 4 (25) | 7 (44) | 0 | 11 (34) |
  Surgery for metastatic site | 2 (17) | 0 | 0 | 2 (6) |