Table 1 Association of HSDL2 expression levels with different clinicopathologic characteristics in cholangiocarcinoma
Clinicopathologic characteristics | HSDL2 expression | p value | |
|---|---|---|---|
| Â | Low | High | Â |
| Â | Count(n%) | Count(n%) | Â |
Sex | |||
 Male | 23(36.5) | 10(15.9) |  |
 Female | 16(25.4) | 14(22.2) | 0.182 |
Age, years | |||
 ≤60 | 15(23.8) | 10(15.9) |  |
 >60 | 24(38.1) | 14(22.2) | 0.801 |
Position | |||
 Intrahepatic | 3(4.8) | 2(3.2) |  |
 Perihilar | 20(31.7) | 15(23.8) |  |
 Distal | 16(25.4) | 7(11.1) | 0.632 |
Histologic grade | |||
 Well | 1(1.6) | 2(3.2) |  |
 Moderate | 31(49.2) | 14(22.2) |  |
 Poor | 7(11.1) | 8(12.7) | 0.179 |
Diameter of tumor | |||
 ≤3 cm | 21(33.3) | 20(31.7) |  |
 >3 cm | 18(28.6) | 4(6.3) | 0.017 |
Number of tumor | |||
 Single | 25(39.7) | 21(33.3) | 0.042 |
 Multiple | 14(22.2) | 3(4.8) |  |
Lymphatic metastasis | |||
 Positive | 9 (14.3) | 4(6.3) |  |
 Negative | 23(36.5) | 15(23.8) | 0.820 |
 Unknown | 7(11.1) | 5(7.9) |  |
Distant metastasis | |||
 Positive | 1(1.6) | 1(1.6) |  |
 Negative | 30(47.6) | 18(28.6) | 1.000 |
 Unknown | 8(12.7) | 5(7.9) |  |
Vascular invasion | |||
 Positive | 19(30.2) | 4(6.3) |  |
 Negative | 12(19.0) | 11(17.5) | 0.028 |
 Unknown | 8(12.7) | 9(14.3) |  |
TNM stage | |||
 Stage I-II | 19(30.2) | 14(22.2) |  |
 Stage III-IV | 15(23.8) | 8(12.7) | 0.565 |
 Unknown | 5(7.9) | 2(3.2) |  |
HBV infection | |||
 Positive | 4(6.3) | 0(0.0) |  |
 Negative | 34(54.0) | 24(38.1) | 0.266 |
 Unknown | 1(1.6) | 0(0.0) |  |
ALT | |||
 ≤60 | 10(15.9) | 4(6.3) |  |
 >60 | 28(44.4) | 20(31.7) | 0.376 |
 Untested | 1(1.6) | 0(0.0) |  |
AST | |||
 ≤45 | 8(12.7) | 4(6.3) |  |
 >45 | 30(47.6) | 20(31.7) | 0.924 |
 Untested | 1(1.6) | 0(0.0) |  |
Albumin:globulin | |||
 <1.2 | 6(9.5) | 7(11.1) |  |
 ≥1.2 | 32(50.8) | 17(27.0) | 0.208 |
 Untested | 1(1.6) | 0(0.0) |  |
Cholesterol | |||
 ≤ 5.23 | 18(28.6) | 3(4.8) |  |
 >5.23 | 19(30.2) | 20(31.7) | 0.005 |
 Untested | 2(3.2) | 1(1.6) |  |
Triglyceride | |||
 ≤1.7 | 15(23.8) | 5(7.9) |  |
 >1.7 | 22(34.9) | 18(28.6) | 0.133 |
 untested | 2(3.2) | 1(1.6) |  |
CEA level, ng/mL | |||
 ≤5 | 25(39.7) | 17(27.0) |  |
 >5 | 5(7.9) | 4(6.3) | 1.000 |
 Untested | 9(14.3) | 3(4.8) |  |
AFP level, ng/mL | |||
 ≤20 | 29(46.0) | 21(33.3) |  |
 >20 | 0(0.0) | 0(0.0) | — |
 untested | 10(15.9) | 3(4.8) |  |
CA153 level, IU/mL | |||
 ≤28 | 29(46.0) | 20(31.7) |  |
 >28 | 0(0.0) | 1(1.6) | 0.420 |
 untested | 9(14.3) | 4(6.3) |  |
CA199 level, IU/mL | |||
 ≤37 | 9(14.3) | 2(3.2) |  |
 >37 | 21(33.3) | 20(31.7) | 0.139 |
 Untested | 9(14.3) | 2(3.2) |  |