Fig. 6

P53 inhibits SLC7A11 transcription by binding to its promoter. A After transfecting RBE cells with vector and P53 constructs, the SLC7A11 mRNA level was detected by qRT-PCR. B Map of P53 binding site sequence. C Schematic illustration of potential P53 binding sites in the SLC7A11 promoter. D RBE cells were co-transfected with luciferase reporter constructs containing the wild-type or mutant SLC7A11 promoter and P53 overexpression plasmid or control vector. Data are presented as mean ± SD (n=3). **p < 0.01 and ***p < 0.001