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Table 1 Clinicopathological characteristics

From: Gallbladder cancer mimicking perihilar cholangiocarcinoma—considerable rate of postoperative reclassification with implications for prognosis

Variable

All (pCCA and GBC)

pCCA confirmed (n = 48)

GBC (n = 11)

P value

Age, md (IQR)

62 (53–69)

58 (50–68)

71 (61–75)

0.015b

Gender

   

0.176c

 Women, n (%)

25 (42)

18 (38)

7 (64)

 

 Men, n (%)

34 (58)

30 (63)

4 (36)

 

BMI, md (IQR)

24 (22–27)

24 (22–27)

25 (24–28)

0.330b

PSC (yes), n (%)

7 (12)

7 (15)

0 (0)

0.328c

ASA ≥ 3 (missing data n = 1), n (%)

18 (31)

14 (30)

4 (36)

0.724c

Bilirubin, micromol/L (missing data n = 3), md (IQR)

12 (8–20)

12 (8–20)

16 (10–21)

0.410b

GPS ≥ 1 (missing data n = 11), n (%)

39 (81)

34 (83)

5 (71)

0.601c

Radiology

   

0.297c

 CT only, n (%)

38 (64)

29 (60)

9 (82)

 

 CT + MRI, n (%)

21 (36)

19 (40)

2 (18)

 

Preoperative biliary drainage (ERC/PTC), n (%)

56 (95)

46 (96)

10 (91)

0.260c

Preoperative cholangitis, n (%)

10 (17)

9 (19)

1 (9)

0.669c

PVE, n (%)

18 (31)

16 (33)

2 (18)

0.476c

Bismuth-Corlette class, n (%)

   

0.004c

 I

6 (10)

3 (6)

3 (27)

 

 II

13 (22)

7 (15)

6 (55)

 

 IIIa

27 (46)

25 (52)

2 (18)

 

 IIIb

7 (12)

7 (15)

0

 

 IV

6 (10)

6 (13)

0

 

Type of resection

   

0.028c

 Right hemihepatectomy

4 (7)

4 (8)

0

 

 Extended right hemihepatectomy

38 (64)

31 (65)

7 (64)

 

 Left hemihepatectomy

3 (5)

3 (6)

0

 

 Extended left hemihepatectomy

6 (10)

6 (13)

0

 

 Bisegmentectomy 4b-5

3 (5)

0

3 (27)

 

 Isolated extrahepatic bile duct resection

5 (8)

4 (8)

1 (9)

 

Portal vein resection, n (%)

13 (22)

11 (23)

2 (18)

1.000c

T ≥ 3, n (%) a

26 (45)

16 (33)

10 (91)

 

T4, n (%) a

5 (8)

3 (6)

2 (18)

 

N1 (missing data n = 3), n (%)

34 (61)

25 (56)

9 (82)

0.171c

Pn1 (missing data n = 2), n (%)

55 (96)

44 (96)

11 (100)

1.000c

LV1 (missing data n = 2), n (%)

49 (86)

38 (83)

11 (100)

0.332c

R1, n (%)

50 (85)

42 (88)

8 (73)

0.347c

Adjuvant therapy (missing data n = 11), n (%)

4 (8)

4 (10)

0 (0)

1.000c

  1. ASA American Society of Anesthesiologists physical status classification, BMI Body mass index, CT Computerized tomography, ERC Endoscopic retrograde cholangiography, GBC Gallbladder cancer, GPS Glasgow Prognostic Score, IQR Interquartile range, LV1 Lymphovascular invasion, MRI Magnetic resonance imaging, N1 Lymph node metastasis; pCCA perihilar cholangiocarcinoma, PSC Primary sclerosing cholangitis, PTC Percutaneous transhepatic cholangiography, PVE Portal vein embolization, R1 Microscopically positive resection margin, T ≥ 3 tumor extension 3–4. T4 tumor extension 4
  2. aAccording to the separate AJCC/TNM criteria for perihilar cholangiocarcinoma and gallbladder cancer respectively
  3. bMann-Whitney U test
  4. cFisher’s exact test