Effect of perioperative goal-directed fluid therapy on postoperative complications after thoracic surgery with one-lung ventilation: a systematic review and meta-analysis

Li, Xuan; Zhang, Qinyu; Zhu, Yuyang; Yang, Yihan; Xu, Wenxia; Zhao, Yufei; Liu, Yuan; Xue, Wenqiang; Fang, Yu; Huang, Jie

doi:10.1186/s12957-023-03169-5

Table 1 Characteristics of the included studies

From: Effect of perioperative goal-directed fluid therapy on postoperative complications after thoracic surgery with one-lung ventilation: a systematic review and meta-analysis

Reference	Country	Study type	Population (n)	Surgery	E group	Goal	C group	Outcomes
Wang et al. 2021 [17]	China	RCT	GDFT: n = 40 Control: n = 34	Lung cancer surgery	GDFT	SV 10%	CFT	Postoperative complications; Fluid balance Hemodynamic indexes; LOS; Inflammatory factors; Recovery time of bowel function.
Veelo et al. 2017 [21]	Netherlands	Observational study	GDFT: n = 100 Control: n = 99	Esophageal surgery	GDFT	Optimal SV	CFT	Postoperative complications; Mortality; Length of ICU and hospital stay; Fluid balance.
Zhang et al. 2013 [11]	China	RCT	GDFT: n = 30 Control: n = 30	Thoracoscopy lobectomy	GDFT	SVV 10% ± 1% CI > 2.5 ml min⁻¹ m⁻²	CFT	Postoperative complications; P/F ratio; Fluid balance; LOS.
Xu et al. 2017 [16]	China	RCT	GDFT: n = 84 Control: n = 84	Thoracoscopy lobectomy	GDFT	SVV 10%-13% CI > 2.5 ml min⁻¹ m⁻²	CFT	Postoperative complications; P/F ratio; Inflammatory factors; LOS; Respiratory mechanics.
Bahlmann et al. 2019 [4]	Sweden	RCT	GDFT: n = 30 Control: n = 29	Oesophagectomy	GDFT	Optimal SV CI > 2.5 ml min⁻¹ m⁻² MAP > 65 mmHg	CFT	Postoperative complications; Length of ICU and hospital stay; Mortality; Fluid balance; Recovery time of bowel function.
Mukai et al. 2020 [18]	Japan	RCT	GDFT: n = 115 Control: n = 117	Oesophagectomy	GDFT	SVV < 8%; SV decrease < 10% BP > 90 mmHg	CFT	Postoperative complications; Mortality; Length of ICU and hospital stay; Recovery time of bowel function.
Sahutoglu et al. 2018 [22]	Turkey	Observational study	GDFT: n = 43 Control: n = 45	Lobectomy	GDFT	SVV < 13%	CFT	Postoperative complications; Fluid balance.
Kaufmann et al. 2017 [23]	Germany	RCT	GDFT: n = 48 Control: n = 48	Lung surgery	GDFT	SVV < 10% CI > 2.5 ml min⁻¹ m⁻² MAP > 70 mmHg	CFT	Postoperative complications; LOS; Hemodynamic indexes.
Tang et al. 2021 [24]	China	RCT	GDFT: n = 33 Control: n = 32	Minimally invasive esophagectomy	GDFT	SVV < 11%	CFT	Postoperative complications; Mortality; LOS; Fluid balance.
Wang et al. 2022 [25]	China	RCT	GDFT: n = 78 Control: n = 81	Thoracoscopy lobectomy	GDFT	rScO₂ ± 20% (baseline level)	CFT	Postoperative complications; Inflammatory factors; Awakening time; VAS score.
Li et al. 2021 [26]	China	RCT	GDFT: n = 59 Control: n = 59	Thoracoscopy lobectomy	GDFT	SVV 10%-13% CI > 2.5 ml min⁻¹ m⁻²	RFT	Postoperative complications; Mortality; Length of hospital stay; Fluid balance.

BP blood pressure, C group control group, CI cardiac index, CFT conventional fluid therapy, E group experimental group, GDFT goal-directed fluid therapy, LOS length of hospital stay, MAP mean arterial pressure, RCT randomized controlled trial, rScO₂ regional saturation of cerebral oxygenation, RFT restrictive fluid therapy, SV stroke volume, SVV stroke volume variation

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ISSN: 1477-7819

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