Table 2 Clinicopathological factors of PDAC patients with non-tumor and tumor pancreatic tissues (n = 23) and comparison between CXCR4 underexpression (n = 13) versus overexpression (n = 10) in stroma
From: The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer
Characteristics | Case (n = 23) | CXCR4 underexpression (n = 13) | CXCR4 overexpression (n = 10) | P-value |
|---|---|---|---|---|
M ± SEM | M ± SEM | M ± SEM | ||
Age (years) | 64.4 ± 2.2 | 66.8 ± 2.6 | 61.3 ± 3.7 | 0.23 |
Overall survival (OS, months) | 25.0 ± 4.2 | 24.5 ± 6.2 | 25.50 ± 5.6 | 0.56 |
Disease-free survival (DFS, months) | 21.9 ± 4.5 | 22.1 ± 6.7 | 21.50 ± 6.1 | 0.98 |
Gender | n (%) | n (%) | n (%) | |
Male | 11 (47.8) | 6 (46.2) | 5 (50.0) | 0.99 |
Female | 12 (52.2) | 7 (53.8) | 5 (50.0) | |
T status | ||||
T1/T2 | 20 (87.0) | 12 (92.3) | 8 (80.0) | 0.56 |
T3/T4 | 3 (13.0) | 1 (7.7) | 2 (20.0) | |
N status | ||||
N0 | 11 (47.8) | 5 (38.5) | 6 (60.0) | 0.34 |
N1 | 10 (43.5) | 6 (46.2) | 4 (40.0) | |
N2 | 2 (8.7) | 2 (15.4) | 0 (0.0) | |
M status | ||||
No | 23 (100.0) | 13 (100.0) | 10 (100.0) | - |
TNM stage | ||||
I/IIA | 10 (43.5) | 5 (38.5) | 5 (50.0) | 0.69 |
IIB/III | 13 (56.5) | 8 (61.5) | 5 (50.0) | |
Tumor differentiation | ||||
Well/moderate | 18 (78.3) | 11 (84.6) | 7 (70.0) | 0.62 |
Poor | 5 (21.7) | 2 (15.4) | 3 (30.0) | |
Tumor location | ||||
Head | 16 (69.6) | 9 (69.2) | 7 (70.0) | 0.99 |
Body/tail | 7 (30.4) | 4 (30.8) | 3 (30.0) | |
Vascular invasion | ||||
Absent | 15 (65.2) | 9 (69.2) | 6 (60.0) | 0.69 |
Present | 8 (34.8) | 4 (30.8) | 4 (40.0) | |
Lymphatic invasion | ||||
Absent | 14 (60.9) | 7 (53.8) | 7 (70.0) | 0.69 |
Present | 9 (39.1) | 6 (46.2) | 3 (30.0) | |
Neural invasion | ||||
Absent | 4 (17.4) | 3 (23.1) | 1 (10.0) | 0.60 |
Present | 19 (82.6) | 10 (76.9) | 9 (90.0) | |
Local recurrence | ||||
Absent | 16 (69.6) | 8 (61.5) | 8 (80.0) | 0.40 |
Present | 7 (30.4) | 5 (38.5) | 2 (20.0) | |
Distant metastasis | ||||
Absent | 13 (56.5) | 7 (53.8) | 6 (60.0) | 0.99 |
Present | 10 (43.5) | 6 (46.2) | 4 (40.0) | |
Exitus | ||||
No | 11 (47.8) | 6 (46.2) | 5 (50.0) | 0.99 |
Yes | 12 (52.2) | 7 (53.8) | 5 (50.0) | |