Table 3 Univariate and multivariate analysis of prognostic factor of disease-free survival

Age

0.99

0.97–1.02

0.701

Gender

0.534

 Male

Reference

 Female

0.82

0.43–1.55

pT stage

0.294

 T1–2

Reference

 T3–4

2.14

0.52–8.89

pN stage

0.051

 N0

Reference

 N + 

1.89

0.99–3.62

pTNM stage

0.004

0.393

 I

Reference

0.009

Reference

 II

1.92

0.24–15.18

0.536

1.76

0.22–13.96

0.593

 III

5.42

0.74–39.78

0.097

4.69

0.46–48.06

0.192

CEA

0.571

  <  = 5 ng/L

Reference

  > 5 ng/L

1.20

0.64–2.25

CA199

0.947

  <  = 37 U/ml

Reference

  > 37 U/ml

1.02

0.49–2.10

Number of lymph nodes

0.99

0.97–1.02

0.600

Number of negative lymph nodes

0.97

0.95–0.99

0.025

Perineural invasion

0.057

 No

Reference

 Yes

1.88

0.98–3.59

Vascular invasion

0.006

0.116

 No

Reference

Reference

 Yes

2.40

1.28–4.52

0.59

0.30–1.14

Histological differentiation

0.559

 Well differentiated

Reference

 Moderately differentiated

0.34

0.04–2.71

0.307

 Poor differentiated

0.94

0.43–2.07

0.875

 Mucinous

1.48

0.39–5.58

0.566

Adjuvant chemotherapy

0.025

 No

Reference

 Yes

0.48

0.25–0.93

Metastasis in no. 201 LNs

0.006

0.673

 No

Reference

Reference

 Yes

2.48

1.28–4.83

1.31

0.38–4.52

Metastasis in no. 202 LNs

0.004

0.350

 No

Reference

Reference

 Yes

3.19

1.46–6.95

1.54

0.62–3.84

Metastasis in no. 203 LNs

0.073

 No

Reference

 Yes

2.94

0.91–9.57

Metastasis in no. 223 LNs

 < 0.001

0.028

 No

Reference

Reference

 Yes

9.13

2.73–30.5

4.59

1.18–17.86