Table 2 Univariable and multivariable analysis of factors associated with relapse-free survival in patients with high grade rectal neuroendocrine neoplasms

Sex (female/male)

0.964

0.372–2.495

0.938

Age (> 65/ ≤ 65)

2.133

0.590–7.714

0.138

Tumor size (> 2.0 cm/ ≤ 2.0 cm)

0.497

0.141–1.755

0.174

PLR (> 116.0/ ≤ 116.0)

1.719

0.656–4.508

0.295

NLR (> 2.45/ ≤ 2.45)

1.815

0.660–4.992

0.205

PNI (≤ 49.13/ > 49.13)

2.431

0.875–6.755

0.055

3.997

1.379–11.581

0.011

ALP (> 100.0 U/L/ ≤ 100.0 U/L)

2.428

0.711–8.290

0.066

3.051

1.011–9.205

0.048

Ki-67 (> 65%/ ≤ 65%)

1.232

0.475–3.197

0.667

Histology (NEC/MANEC)

0.563

0.167–1.890

0.267

T stage (T3 + T4/T1 + T2)

1.731

0.594–5.047

0.376

LNR (> 0.40/ ≤ 0.40)

5.183

1.757–15.290

0.0002

6.639

2.224–19.817

0.0007

Microvascular invasion (positive/negative)

1.058

0.297–3.770

0.928

Perineural invasion (positive/negative)

0.743

0.198–2.793

0.688