Table 1 Basic information about the included studies
From: Meta analysis of the diagnostic value of circulating miRNA in benign and malignant pulmonary nodules
First author/year | Country | Ethnicity | Sample size | miRNA profiles | Sample source | TP | FP | FN | TN | |
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Â | Â | Â | Â | |||||
Shen 2011 [11] | United States | Caucasian / Black | 32 | 33 | miR-21, miR-210(up-regulated) miR-486-5p(down-regulated) | Plasma miRNA | 24 | 5 | 8 | 28 |
Cazzoli 2013 [12] | Italy | Caucasian/Black | 50 | 30 | miR-151a-5p, miR-30a-3p, miR-200b-5p, miR-629, miR-100 and miR-154-3p (up-regulated) | Plasma miRNA | 48 | 12 | 2 | 18 |
Tang 2013 [13] | China | Asian | 34 | 30 | miR-21, miR-155 (up-regulated) and miR-145 (down-regulated) | Plasma miRNA | 26 | 6 | 8 | 24 |
Wang 2015 [14] | China | Caucasian/Black | 108 | 56 | miR-483-5p, miR-193a-3p, miR-214, miR-25, miR-7(up-regulated) | Serum miRNA | 103 | 3 | 5 | 53 |
Tai 2016 [15] | Japan | Asian | 110 | 47 | a set of 20 miRNAs | Serum miRNA | 98 | 5 | 12 | 42 |
Li 2017 [16] | China | Asian | 20 | 19 | miRNA-21-5p, miRNA-574-5p, CEA, CY-FRA21-1(up-regulated) | Serum miRNA | 18 | 5 | 2 | 14 |
Lin 2017 [17] | China | Caucasian/Black | 69 | 66 | miRs-126, 210 and 205-5p(up-regulated) | Plasma miRNA | 56 | 9 | 13 | 57 |
Lin 2017 [17] | China | Caucasian/Black | 63 | 63 | miRs-126, 210 and 205-5p(up-regulated) | Plasma miRNA | 51 | 9 | 12 | 54 |
Lin 2017 [17] | China | Asian | 49 | 49 | miRs-126, 210 and 205-5p(up-regulated) | Plasma miRNA | 40 | 7 | 9 | 42 |
Fan 2018 [18] | China | Asian | 70 | 22 | miR-15b-5p, miR-20a-5p, miR-19a-3p, miR-92a—3p, miR-16-5p (up-regulated), miR-146b-3p(down-regulated) | Serum miRNA | 56 | 6 | 14 | 16 |
He 2018 [19] | China | Asian | 274 | 122 | hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR—210-3p, hsa-miR-378d and hsa-miR-138-5p | Serum miRNA | 93 | 12 | 181 | 110 |
Xi 2018 [20] | China | Asian | 42 | 15 | miRNA-182(up-regulated) | Plasma miRNA | 35 | 4 | 7 | 11 |
Zhang 2019 [21] | China | Asian | 47 | 12 | miR-185-5p, miR-32-5p, miR-140-3p and let-7f-5p | Plasma miRNA | 40 | 5 | 7 | 7 |
Zhang 2019 [21] | China | Asian | 32 | 8 | miR-185-5p, miR-32-5p, miR-140-3p and let-7f-5p | Plasma miRNA | 24 | 0 | 8 | 8 |
Xi 2019 [22] | China | Asian | 28 | 12 | MiRNA-146a, MiRNA-200b, miRNA-7(up-regulated) | Plasma miRNA | 26 | 2 | 2 | 10 |
Yang 2020 [23] | China | Asian | 75 | 23 | miR-21,Let-7a(up-regulated) | Plasma miRNA | 42 | 4 | 33 | 19 |
Zheng 2022 [24] | China | Asian | 41 | 16 | let-7b-3p,miR-101-3p,miR-125b-5p,miR-150-5p,miR-3168 | Plasma miRNA | 27 | 2 | 14 | 14 |