Table 2 Univariate and multivariate analysis of OS for patients with stage IIIA–N2 NSCLC

Age

4511

  < 65

1932

Reference

  ≥ 65

2579

1.43 (1.33–1.54)

 < 0.01

1.35 (1.25–1.45)

 < 0.01

Sex

4511

 Female

2432

Reference

 Male

2079

1.34 (1.25–1.44)

 < 0.01

1.32 (1.23–1.42)

 < 0.01

Year of diagnosis

4511

 2000–2009

2172

Reference

 2010–2019

2339

0.67(0.61–0.71)

 < 0.01

0.69 (0.64–0.75)

 < 0.01

Race

4511

 White

3664

Reference

 Other

847

0.80 (0.73–0.88)

 < 0.01

0.82 (0.75–0.91)

 < 0.01

Primary site

4511

 Upper lobe

2824

Reference

 Middle lobe

224

1.04 (0.88–1.22)

0.68

1.18 (0.99–1.40)

0.06

 Lower lobe

1463

1.06 (0.98–1.14)

0.17

1.07 (0.99–1.16)

0.08

Laterality

4511

 Left

2084

Reference

 Right

2427

0.95 (0.89–1.02)

0.15

0.97 (0.91–1.05)

0.49

Histologic type

4511

 LUAD

3153

Reference

 LUSC

819

1.24 (1.13–1.36)

 < 0.01

1.10 (1.00–1.21)

0.05

 Large cell

146

1.25 (1.03–1.51)

0.02

1.19 (0.99–1.44)

0.07

 Other

393

1.01 (0.88–1.15)

0.92

0.98 (0.86–1.12)

0.78

T stage

4511

 T1

1785

Reference

 T2

2726

1.24 (1.15–1.33)

 < 0.01

1.23 (1.14–1.32)

 < 0.01

Surgery

4511

 Lobectomy

3773

Reference

 Sublobectomy

471

1.29 (1.15–1.44)

 < 0.01

1.38 (1.23–1.54)

 < 0.01

 Pneumonectomy

267

1.27 (1.10–1.46)

 < 0.01

0.99 (0.85–1.15)

0.89

Surg/Rad Seq

4511

 Non-PORT

2591

Reference

 PORT

1920

0.92 (0.85–0.99)

0.02

1.01 (0.93–1.08)

0.91

Chemotherapy

4511

 No

1455

Reference

 Yes

3056

0.66 (0.61–0.71)

 < 0.01

0.72 (0.66–0.78)

 < 0.01

Regional nodes positive

4511

  < 4

2937

Reference

  ≥ 4

1574

1.36 (1.27–1.47)

 < 0.01

1.48 (1.37–1.59)

 < 0.01