Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation

Table 1 Histopathologic characteristics and follow-up time of 6 cases of microcystic owed prolonged overall survivaladnexal carcinomas (MACs)

Case	Keratin microcysts	Squamous diff.	Follicular diff.	Solid component	PNI	Angiotropism	Inflammation^a	Desmoplasia	Follow-up time (months)
M1	+	+	+	+	−	−	1	+	49
M2	+	+	−	+	−	−	2	+	52
M3	+	−	−	+	−	−	1	+	b
M4	+	+	−	+	−	−	1	+	24
M5	+	+	−	+	−	−	1	+	b
M6	−	+	−	+	−	−	1	+	7

Abbreviations: diff. differentiation, PNI perineural invasion, + present, − absent; ^ainflammation was classified as 1 = minimal and 2 = mild/moderate; b: failed to follow up

ISSN: 1477-7819

Case	Keratin microcysts	Squamous diff.	Follicular diff.	Solid component	PNI	Angiotropism	Inflammation^a	Desmoplasia	Follow-up time (months)
M1	+	+	+	+	−	−	1	+	49
M2	+	+	−	+	−	−	2	+	52
M3	+	−	−	+	−	−	1	+	b
M4	+	+	−	+	−	−	1	+	24
M5	+	+	−	+	−	−	1	+	b
M6	−	+	−	+	−	−	1	+	7

Case	Keratin microcysts	Squamous diff.	Follicular diff.	Solid component	PNI	Angiotropism	Inflammation^a	Desmoplasia	Follow-up time (months)
M1	+	+	+	+	−	−	1	+	49
M2	+	+	−	+	−	−	2	+	52
M3	+	−	−	+	−	−	1	+	b
M4	+	+	−	+	−	−	1	+	24
M5	+	+	−	+	−	−	1	+	b
M6	−	+	−	+	−	−	1	+	7

Case	Keratin microcysts	Squamous diff.	Follicular diff.	Solid component	PNI	Angiotropism	Inflammation^a	Desmoplasia	Follow-up time (months)
M1	+	+	+	+	−	−	1	+	49
M2	+	+	−	+	−	−	2	+	52
M3	+	−	−	+	−	−	1	+	b
M4	+	+	−	+	−	−	1	+	24
M5	+	+	−	+	−	−	1	+	b
M6	−	+	−	+	−	−	1	+	7