The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)

Table 4 Allele frequency and genotype distribution of hTERT rs2736100 and rs2736098 polymorphisms between the recurrence and non-recurrence groups

	Non-recurrence group	Recurrence group	P	OR (95%CI)
	(n = 237)	(n = 75)
rs2736100
TT genotype	54 (22.8)	7 (9.3)	Ref
TG genotype	133 (56.1)	39 (52.0)	0.059	0.44 (0.19–1.05)
GG genotype	50 (21.1)	29 (38.7)	0.001	4.47 (1.80–11.12)
T allele	241 (50.8)	53 (35.3)	Ref
G allele	233 (49.2)	97 (64.7)	0.001	1.89 (1.29–2.77)
rs2736098
GG genotype	135 (57.0)	46 (61.3)	Ref
GA genotype	86 (36.3)	26 (34.7)	0.671	0.89 (0.51–1.54)
AA genotype	16 (6.8)	3 (4.0)	0.353	0.55 (0.15–1.98)
G allele	356 (75.1)	118 (78.7)	Ref
A allele	118 (24.9)	32 (21.3)	0.373	0.82 (0.53–1.27)

hTERT human telomerase reverse transcriptase, Ref reference, OR odds ratio, CI confidence interval

ISSN: 1477-7819