Table 3 Univariate and multivariate analyses of prognostic factors for overall survival and disease-specific survival in patients aged 75 years or older (n = 117)
From: Prognostic factors for gastrectomy in elderly patients with gastric cancer
Overall survival | Disease-specific survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
n | MST (months) | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | MST (months) | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
Sex | – | – | – | 0.229 | – | – | – | – | 0.890 | – | – |
Males | 82 | 74.0 | 1.16 (0.63–2.24) | – | – | – | – | 1.00 | – | – | – |
Females | 35 | 70.8 | 1.00 | – | – | – | – | 1.18 (0.44–3.68) | – | – | – |
ASA-PS | – | – | – | 0.041* | – | – | – | – | 0.014* | – | 0.002* |
1 | 30 | – | 1.00 | – | – | – | – | 1.00 | – | 1.00 | – |
2 | 65 | 80.2 | 1.29 (0.64–2.71) | – | – | – | – | 1.12 (0.33–4.31) | – | 0.14 (0.01–1.53) | – |
3 | 22 | 34.3 | 2.88 (1.30–6.47) | – | – | – | – | 3.58 (1.06–13.87) | – | 9.11 (1.20–103.77) | – |
Surgery | – | – | – | 0.040* | – | 0.636 | – | – | 0.036* | – | 0.476 |
DG | 50 | 70.8 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
TG | 23 | 32.4 | 1.54 (0.73–3.07) | – | 1.35 (0.52–3.32) | – | – | 1.72 (0.51–5.18) | – | 2.48 (0.20–26.78) | – |
LADG | 25 | – | 0.36 (0.08–1.07) | – | 0.68 (0.14–2.43) | – | – | 1.18e−9 (0–0.65) | – | 1.33e−9 (0–28.12) | – |
Cardiectomy | 11 | 33.0 | 2.54 (1.09–5.44) | – | 1.75 (0.62–4.62) | – | 50.6 | 3.46 (1.03–10.56) | – | 0.23 (0.02–2.35) | – |
LR | 8 | – | 0.87 (0.13–3.00) | – | 0.71 (0.10–3.20) | – | – | 1.16e−9 (5.39e−16–7.35e−130) | – | 5.54e−10 (0–24.97) | – |
Histology | – | – | – | 0.420 | – | – | – | – | 0.134 | – | – |
Intestinal | 76 | 74.0 | 1.00 | – | – | – | – | 1.00 | – | – | – |
Diffuse | 41 | 51.6 | 1.30 (0.72–2.30) | – | – | – | – | 2.24 (0.88–5.87) | – | – | – |
Tumor size | – | – | – | 0.018* | – | 0.793 | – | 0.003* | – | 0.358 | |
<5 cm | 68 | 80.2 | 1.00 | – | 1.12 (0.46–2.81) | – | – | 1.00 | – | 2.69 (0.31–23.75) | – |
≥5 cm | 49 | 50.5 | 1.93 (1.09–3.47) | – | 1.00 | – | – | 3.68 (1.38–11.49) | – | 1.00 | – |
Depth of invasion (T) | – | – | – | <0.001* | – | 0.317 | – | – | <0.001* | – | 0.005* |
T1 | 57 | 80.2 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
T2 | 18 | 88.8 | 0.54 (0.15–1.47) | – | 0.30 (0.06–1.09) | – | – | 1.26e−8 (0–15.07) | – | 2.86e−10 (0–2.92) | – |
T3 | 20 | 38.4 | 2.16 (1.01–4.48) | – | 0.65 (0.18–2.15) | – | – | 20.02 (3.55–374.36) | – | 15.44 (1.16–642.77) | – |
T4 | 22 | 25.2 | 2.50 (1.22–5.03) | – | 0.87 (0.27–2.61) | – | 50.5 | 33.63 (6.43–617.14) | – | 10.86 (0.65–432.23) | – |
Lymphatic invasion (ly) | – | – | – | 0.013* | – | 0.328 | – | – | 0.013* | – | 0.578 |
ly0, ly1 | 73 | 88.8 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
ly2, ly3 | 43 | 41.3 | 2.29 (1.29–4.08) | – | 1.49 (0.66–3.34) | – | – | 3.90 (1.51–11.21) | – | 1.79 (0.22–14.91) | – |
Venous invasion (v) | – | – | – | 0.001* | – | 0.944 | – | – | <0.001* | – | 0.013* |
v0, v1 | 77 | 80.2 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
v2, v3 | 40 | 37.2 | 2.18 (1.22–3.87) | – | 1.02 (0.44–2.26) | – | 50.6 | 11.97 (3.94–51.74) | – | 9.38 (6.56–82.05) | – |
Lymph node metastasis (N) | – | – | – | <0.001* | – | 0.178 | – | – | <0.001* | – | 0.010* |
N0 | 73 | 88.8 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
N1 | 20 | 41.3 | 2.91 (1.29–6.58) | – | 2.41 (0.84–6.84) | – | 51.6 | 6.30 (1.89–24.18) | – | 5.40 (0.67–55.78) | – |
N2 | 13 | – | 3.19 (1.25–7.71) | – | 0.92 (0.18–3.80) | – | – | 1.65e−8 (0–3.37) | – | 8.07e−11 (0–1.20) | – |
N3 | 11 | 17.9 | 8.82 (4.21–19.22) | – | 3.76 (0.86–15.50) | – | 25.2 | 28.24 (7.99–115.80) | – | 6.70 (0.34–219.73) | – |
Clavien–Dindo | – | – | – | <0.001* | – | <0.001* | – | – | <0.001* | – | <0.001* |
0 | 97 | 70.8 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
I | 5 | – | 0.86 (0.14–2.84) | – | 0.52 (0.07–2.21) | – | – | 1.24 (0.06–6.35) | – | 0.24 (0.01–3.42) | – |
II | 6 | 88.8 | 0.28 (0.01–1.32) | – | 0.82 (0.04–5.79) | – | – | 6.15e−9 (0–2.07) | – | 12.78 (0–5.28e298) | – |
III | 5 | 37.2 | 1.81 (0.43–5.05) | – | 2.33 (0.44–10.33) | – | – | 1.92 (0.10–9.83) | – | 1.09 (0.01–104.71) | – |
IV | 1 | 7.7 | 27.25 (1.39–184.77) | – | 7.69 (0.35–67.41) | – | 7.7 | 8.73e16 (18.30–1.89e109) | – | 8.31e18 (15.71-NC) | – |
V | 3 | 1.1 | 5.21e10 (87.65–1.64e31) | – | 1.08e11 (57.71–9.25e141) | – | 1.1 | 7.72e31 (255.05-NC) | – | 5.71e33 (296.06–3.28e306) | – |
Onodera PNI | – | – | – | <0.001* | – | 0.056 | – | – | 0.010* | – | 0.698 |
<40 | 29 | 33.0 | 2.65 (1.47–4.69) | – | 2.03 (0.97–4.17) | – | – | 2.35 (0.86–5.98) | – | 1.42 (0.23–9.56) | – |
≥40 | 88 | 80.2 | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
Modified GPS | – | – | – | 0.375 | – | – | – | – | 0.574 | – | – |
0 | 96 | 70.8 | 1.00 | – | – | – | – | 1.00 | – | – | – |
1 | 7 | – | 0.82 (0.13–2.71) | – | – | – | – | 1.24 (0.06–6.21) | – | – | – |
2 | 14 | 34.3 | 1.54 (0.66–3.15) | – | – | – | – | 1.59 (0.36–4.89) | – | – | – |
Chemotherapy | – | – | – | 0.562 | – | – | – | – | 0.252 | – | – |
Yes | 24 | 50.6 | 1.00 | – | – | – | – | 1.00 | – | – | – |
No | 93 | 74.0 | 1.42 (0.74–2.60) | – | – | – | – | 2.77 (1.05–7.03) | – | – | – |