Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

Table 4 DEMs in HCC tissue and their potential target genes

miRNA	Adj. P	logFC	Target genes
hsa-mir-106b	1.94E-41	1.49	ANKRD29, IL1RAP, ADARB1, ARID4B, EPHA4, FBXL5, PDCD1LG2, PKD2, PTPN4, SLC40A1
hsa-mir-148b	9.59E-22	1.37	ESR1, ABCB7, B4GALT6, CDK19, LDLR, MXD1, NPTN, RPS6KA5, SOS2, SZRD1
hsa-mir-151	2.61E-21	1.14	AGO2, ZFAND5, CLK1, AQP4, CASD1, RPS6KA5, FAM104A, NAA15, YTHDF3, HIF1A
hsa-mir-221	7.37E-21	1.66	ESR1, FOS, CXCL12, CDKN1B, GABRA1, PANK3, TCF12, HECTD2, RFX7, TMCC1
hsa-mir-18a	2.16E-20	2.48	ESR1, NEDD9, BBX, INADL, MAP7D1, PHF19, RORA, ZBTB47, CDK19, DICER1
hsa-mir-200b	4.50E-17	−3.15	MAGEC2, ESM1, TCEB1, TRIM33, LHFP, PTPN21, ARHGAP6, VASH2, HIPK3, NR5A2
hsa-mir-224	4.85E-15	−71.38	NRCAM, CPNE8, ZNF207, ACSL4, RNF144B, SH3KBP1, RNF38, SLC4A4, GPR158, GGNBP2
hsa-mir-200a	5.03E-14	−2.29	COL15A1, MYBL1, ZEB2, ATP8A1, DCP2, TMEM170B, ZBTB34, DUSP3, TRHDE, RSAD2
hsa-mir-182	1.41E-06	−2.69	NRCAM, ABHD13, MFAP3, PCNX, NADK2, CAMSAP2, SLC39A9, NCALD, ANK3, HOXA9
hsa-mir-142-5p	6.59E-06	−1.49	ANKRD29, IGF2BP3, IGSF3, ZFP36, ZFPM2, BAI3, AFF4, DIAPH2, AHR, ARID4B

Adj. P: adjusted P value, FC: fold change
Positive logFC values denote up-regulated miRNAs, while negative logFC values denote down-regulated miRNAs. If there were more than ten genes predicted by miRDB, only ten genes were listed in the table

ISSN: 1477-7819