Table 4 Clinicopathological characteristics of the 12 patients in the validation set
| Â | Non-relapse | Relapse | p value |
|---|---|---|---|
Case number | 8 | 4 | Â |
Age (mean ± SD) | 63.0 ± 10.3 | 66.7 ± 8.0 | 0.425 |
Gender | |||
 Male | 4 | 4 | 0.08 |
 Female | 4 | 0 |  |
Tumor location | |||
 Upper/middle thoracic | 5 | 2 | 0.67 |
 Lower thoracic | 3 | 2 |  |
Histological grade | |||
 Well/moderate | 7 | 2 | 0.16 |
 Poorly | 1 | 2 |  |
Pathologic tumor depth | |||
 T1-2 | 2 | 1 | 1.00 |
 T3-4 | 6 | 3 |  |
 Lymph node metastasis | |||
 N0 | 3 | 1 | 0.66 |
 N1-3 | 5 | 3 |  |
Distant metastasis | |||
 M0 | 8 | 4 | - |
 M1 | 0 | 0 |  |
TNM stage | |||
 1–2 | 3 | 1 | 0.66 |
 3–4 | 5 | 3 |  |
Lymphatic vessel invasion | |||
 Negative | 3 | 1 | 0.66 |
 Positive | 5 | 3 |  |
Venous invasion | |||
 Negative | 2 | 1 | 1.00 |
 Positive | 6 | 3 |  |
Curability | |||
 R0 | 8 | 4 | – |
 R1 | 0 | 0 |  |
 Preoperative chemotherapy | 5 | 3 | – |
Preoperative CRT | 0 | 0 | Â |
 Postoperative chemotherapy | 2 | 3 | – |
 Postoperative CRT | 0 | 0 |  |
 Observation period (month, mean ± SD) | 64.6 ± 18.3 | 51.1 ± 33.6 | 0.049 |
 Duration between surgery and tumor relapse | – | 8.8 ± 2.9 | – |
Type of tumor relapse | |||
 Liver (H) | 0 | 2 |  |
 Lymph node (Ly) | 0 | 2 |  |
 miR-574-3p (<0.7) | 1 | 3 | 0.029 |
 miR-574-3p (≥0.7) | 7 | 1 |  |
 miR-106b (<1.00) | 1 | 1 | 0.576 |
 miR-106b (≥1.00) | 7 | 3 |  |
 miR-1303 (<1.20) | 5 | 2 | 0.576 |
 miR-1303 (≥1.20) | 3 | 2 |  |