Table 1 Patient characteristics of all patients undergoing SLN biopsy (cohort 1) and overall survival (OS)
Parameter | Value | N (%) | 5-year OS | 95 % CI | 8-year OS | 95 % CI | p value log-rank test |
|---|---|---|---|---|---|---|---|
Płeć | Female | 1021 (57.9 %) | 84.8 | (82.2–87.4) | 78.6 | (74.9–82.5) | 0.001 |
Male | 743 (42.1 %) | 72.3 | (68.5–76.4) | 66.6 | (61.6–72.0) | ||
Tumor type | NM | 695 (39.4 %) | 74.0 | (70.2–78.0) | 67.5 | (62.8–72.5) | 0.0001 |
SSM | 516 (29.25 %) | 87.1 | (83.7–90.6) | 82.2 | (77.0–87.9) | ||
ALM | 44 (2.49 %) | 65.0 | (51.0–82.8) | 65.0 | (51.0–82.8) | ||
LMM | 122 (6.92 %) | 84.3 | (76.6–92.7) | 77.5 | (66.7–90.1) | ||
Other | 9 (0.51 %) | 83.3 | (58.3–100.0) | 83.3 | (58.3–100.0) | ||
NA | 378 (21.43 %) | 80.0 | (75.0–85.4) | 73.2 | (66.1–81.0) | ||
Clark level | 2 | 253 (14.34 %) | 90.7 | (86.3–95.3) | 84.2 | (77.0–92.2) | 0.001 |
3 | 818 (46.37 %) | 86.1 | (83.3–89.0) | 78.8 | (74.5–83.4) | ||
4 | 490 (27.78 %) | 68.7 | (63.8–73.9) | 65.4 | (60.1–71.3) | ||
5 | 110 (6.24 %) | 54.7 | (44.9–66.6) | 47.2 | (36.2–61.5) | ||
NA | 93 (5.27 %) | 78.9 | (69.7–89.3) | 78.9 | (69.7–89.3) | ||
Ulceration of primary tumor | 0 | 931 (52.78 %) | 90.4 | (88.1–92.7) | 84.8 | (81.0–88.8) | 0.001 |
1 | 713 (40.59 %) | 65.7 | (61.7–70.0) | 58.9 | (54.1–64.3) | ||
NA | 115 (6.63 %) | 79.5 | (70.9–89.1) | 76.5 | (66.8–87.7) | ||
Extracapsular involvement of sentinel node metastases | 0 | 321 | 62.4 | (56.7–68.7) | 54.2 | (47.5–61.7) | 0 |
1 | 96 | 33.8 | (25.1–45.6) | 27.0 | (18.6–39.2) | ||
NA | 1341 | 88.6 | (86.4–90.7) | 84.2 | (81.0–87.4) | ||
Mitotic index | <1/mm2 | 123 (15.28 %) | 92.9 | (86.0–100.0) | 92.9 | (86.0–100.0) | 0.002 |
1/mm2 | 142 (17.64 %) | 89.9 | (81.2–99.5) | 89.9 | (81.2–99.5) | ||
2–5/mm2 | 262 (32.55 %) | 88.3 | (83.3–93.6) | 84.7 | (78.0–92.0) | ||
>5/mm2 | 278 (34.53 %) | 63.1 | (56.4–70.7) | 61.6 | (54.5–69.7) | ||
Breslow thickness | ≤1 mm | 343 (19.44 %) | 94.2 | (91.0–97.4) | 88.7 | (82.7–95.2) | 0.001 |
1.01–2.00 mm | 449 (25.45 %) | 91.5 | (88.5–94.7) | 87.8 | (83.1–92.8) | ||
2.01–4.00 mm | 519 (29.42 %) | 75.6 | (71.1–80.3) | 68.0 | (61.8–74.7) | ||
>4 mm | 398 (22.56 %) | 60.8 | (55.5–66.6) | 54.4 | (48.4–61.0) | ||
NA | 55 (3.12 %) | 75.4 | (62.8–90.4) | 70.9 | (57.1–88.1) | ||
Sentinel node metastases | No | 1413 (80.10 %) | 86.3 | (84.1–88.5) | 80.4 | (77.1–83.9) | 0.001 |
Yes | 351 (19.9 %) | 55.6 | (50.1–61.9) | 49.8 | (43.7–56.8) | ||
All patients | 1764 | 79.5 | (77.2–81.8) | 73.5 | (70.5–76.7) | ||