A giant subcutaneous leiomyosarcoma arising in the inguinal region
© Yajima et al; licensee BioMed Central Ltd. 2005
Received: 29 November 2004
Accepted: 24 February 2005
Published: 24 February 2005
Subcutaneous leiomyosarcoma is a rare condition that accounts for 1% to 2% of all superficial soft tissue malignancies. Approximately 10% of cases arise in the trunk, although the extremities are the most commonly affected.
We report herein the case of a 31-year-old man with a subcutaneous leiomyosarcoma, measuring 124 × 105 mm, arising in the left inguinal region. A wide local excision (with a resection margin ≥ 20 mm) was performed. Histological examination of the resected specimen revealed a leiomyosarcoma with high cellularity and two mitoses per 10 high-power fields. The patient remains well with no evidence of disease 5 years and 8 months after the operation.
This is the first reported case of subcutaneous leiomyosarcoma arising in the inguinal region and also one of the largest tumors reported. The experience of this case and a review of the English-language literature (PubMed, National Library of Medicine, Bethesda, MD, USA) suggest that a resection margin of ≥ 10 mm is recommended when excising this rare tumor.
Subcutaneous leiomyosarcoma arises from smooth muscle in the walls of arterioles and veins. It is a rare tumor accounting for 1% to 2% of all superficial soft tissue malignancies [1–4]. It usually occurs in patients between 50 and 70 years of age [1, 2, 5], with a male predominance ranging from 2:1 to 3:1 [2, 4]. Although most tumors present as a subcutaneous nodule in the extremities, usually measuring 30 mm or less in diameter, about 10% of cases arise in the trunk [1, 2, 4]. We herein report the case of a patient with a giant subcutaneous leiomyosarcoma arising in the inguinal region.
The patient had an uneventful recovery and was discharged on the 9th postoperative day. As the resection margin was negative, no adjuvant treatment was given. He remains well with no evidence of disease 5 years and 8 months after excision.
Although subcutaneous leiomyosarcoma commonly arises in the lower extremities, it occasionally affects the trunk [1, 2, 4]. A review of the English-language literature (PubMed, National Library of Medicine, Bethesda, MD, USA) suggests that the case reported here is the first one arising in the inguinal region and involves one of the largest tumors reported thus far [2, 7]. Earlier authors proposed several prognostic factors for soft tissue sarcomas (including subcutaneous leiomyosarcoma) [2, 6–8]. Factors adversely affecting the prognosis include high mitotic index (≥ 5 mitoses per 10 high-power fields) , high histologic grade , extensive necrosis , nodular growth pattern , deep tumor , and large tumor size . Among them, tumor size (≥ 5 cm) is the strongest independent prognostic factor . In the current case, low mitotic index, low histologic grade and the absence of necrosis favored a good prognosis, while large tumor size, deep tumor and nodular growth pattern were adverse prognostic factors.
As subcutaneous leiomyosarcoma is resistant to radiotherapy and chemotherapy [2, 3, 9], surgical excision provides the only chance of cure. Prognosis after excision is generally considered poor, and even after a wide excision, local recurrence may occur in 40% to 60% of patients, followed by distant metastases in 20% to 40% of cases [1, 2]. Contaminated margins contribute to the frequency of local recurrences [5, 10–12]. In the current case, the resection margin of ≥ 20 mm successfully controlled the tumor. McKee et al.,  demonstrated that resection margins ≥ 10 mm decreased the risk of both local and distant recurrences in patients with soft tissue sarcomas (including subcutaneous leiomyosarcoma). A resection margin of ≥ 10 mm is therefore recommended when excising this rare tumor.
Written consent was obtained from the patient for publication.
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