Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma

Table 1 Correlation between HSPA2 expression and clinicopathologic features of ESCC patients (n = 120)

Parameters	Cases	HSPA2 expression (n)		χ²	P value
		Positive	Negative
Tissues
Cancer	120	90	30	21.343	0.000
Adjacent	120	55	65
Age (years)
≤60	81	64	17	2.140	0.144
>60	39	26	13
Gender
Male	90	69	21	0.533	0.465
Female	30	21	9
Drinking
Yes	75	59	16	1.434	0.231
No	45	31	14
Tumor site
Upper	35	26	9	0.017	0.992
Middle	40	30	10
Lower	45	34	11
Grade
G1	63	49	14	0.672	0.715
G2	30	21	9
G3 + G4	27	20	7
Primary tumor
T1	30	18	12	9.340	0.025^a
T2	31	21	10
T3	42	35	7
T4	17	16	1
TNM stage
I	28	14	14	14.991	0.001^a
II	49	37	12
III	43	39	4
Lymph node metastases
N0	76	51	25	6.890	0.009^a
N+	44	39	5
Recurrence^b
Yes	85	70	15	8.497	0.004^a
No	32	18	14

^aP values considered statistically significant at <0.05; ^bthree patients lost to follow-up because of telephone number changes or home moving. ESCC, esophageal squamous cell carcinoma; G, grade; N, lymph node metastases; T, primary tumor. Drinking alcohol is defined as average amount of drinking alcohol is 50 grams or more per day, and period of drinking continues to 1 year or more. Drinking alcohol parameter: amount of drinking/day × years of drinking.

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