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Table 4 Effect of tumor markers and clinical factors on survival

From: Prognostic value of expression of molecular markers in adenoid cystic cancer of the salivary glands compared with lymph node metastasis: a retrospective study

Marker/factor

 

HR

95% CI

P

c-kit

0, 1+

1

0.297 - 4.251

0.864

 

2+, 3+

1.124

  

EGFR

0

1

0.206 - 2.957

0.716

 

1+, 2+

0.781

  

VEGF

0, 1+

1

0.624 - 11.392

0.198

 

2+, 3+

2.623

  

Sex

Male

1

0.01 - 0.639

0.17

 

Female

0.8

  

Site

Submandibular gland

1

  
 

Parotid gland

0

 

0.995

 

Minor salivary gland

0.33

0.07 - 1.563

0.162

Perineural invasion

Negative

1

0.491- ~ 7.02

0.362

 

Positive

1.856

  

Resection margin

Negative

1

0.173 - 2.505

0.54

 

Positive

0.659

  

Lymph node involvement

Negative

1

0.791 - 14.06

0.049

 

Positive

4.362

  

Treatment

Surgery only

1

  
 

Surgery + RT

0.224

0.033 - 1.508

0.124

 

Surgery + CCRT

0.831

0.113 - 6.127

0.856

Age (year)

<45

1

  
 

≥45

1.078

1.016 ~ 1.143

0.103

Tumor size (cm)

≤2

1

  
 

>2

0.838

0.452 ~ 1.554

0.575

  1. CCRT, concurrent chemoradiation therapy; CI, confidence interval; EGFR, epidermal growth factor receptor; HR, hazard ratio; RT, radiation therapy; VEGF, vascular endothelial growth factor.