A case of parosteal osteosarcoma with a rare complication of myositis ossificans
© Spinelli et al.; licensee BioMed Central Ltd. 2012
Received: 8 July 2012
Accepted: 21 September 2012
Published: 29 November 2012
We report the case of a parosteal osteosarcoma of the distal ulna, treated with wide resection without reconstruction. The patient developed lung metastasis and a mass in the interosseus membrane of the forearm proximally to the osteotomy. The lung mass was found to be a metastasis from parosteal osteosarcoma and the biopsy of the forearm mass revealed a myositis ossificans. The suspicion of a recurrence of parosteal osteosarcoma, already metastatic, led to a second wide resection with no reconstruction. A slice of the radial cortex was taken during this second procedure. From a histological point of view, good margins were achieved and diagnosis of myositis ossificans was confirmed. Two months later, a radius fracture occurred and a synthesis, with plate and screws, as added with poly(methyl methacrylate) (PMMA) to reconstruct the bone loss, was performed. Indication of the reconstructive technique and the complication after distal ulna resection in oncologic surgery are discussed in this paper.
KeywordsDistal ulna resection Parosteal osteosarcoma Ulna Ulna reconstruction
Parosteal osteosarcoma is the most common type of osteosarcoma originating from the cortex, accounting for 5% of all osteosarcomas . Furthermore, the ulna is rarely affected by bone tumors.
Due to the rarity of the localization, distal ulna resection and reconstructive options after oncologic surgery are still debated. The literature provides conflicting choices, with reports advocating no reconstruction after resection [2, 3], soft tissue stabilization procedures  and bone graft augmentation .
Given the lack of consensus in the literature on this rare condition, we present our clinical case in which parosteal osteosarcoma was treated without reconstruction, along with complications occurring after our surgical procedure.
He did not change his job (mild to heavy activity), nor his hours of work.
One year after the last surgical procedure, there was no local recurrence of the tumor or systemic or lung metastasis. The patient had complete ulnar nerve impairment, partial radial nerve deficit (only in the motor component), but the median nerve activity was normal.
During flexion the patient presented a loss of ulnar flexion of 20° and dorsal subluxation of the stump, which was mildly bothering him. He changed his job, but he reported no pain during his daily activities.
The therapy for parosteal osteosarcoma is a large en-bloc resection. Inadequate excision of the tumor leads to a recurrence rate of 80% to 100%. While resection of the ulna is often relatively easy to perform, problems arise in the reconstruction of the defect.
Darrach’s procedure (resection of 1 to 2 cm of the distal ulna) for post traumatic and degenerative conditions is well described; however, patients undergoing oncological resection are different from the former because they are usually younger and highly demanding and reaching good margins for a longer bone resection leads to increased instability of the ulnar stump with dynamic radio-ulnar convergence. Clinically, this condition may lead to pain, weakness, loss of grip strength and dorsal subluxation of the distal ulnar stump, up to digital extensor tendon rupture and radio-carpal instability with ulnar translation of the carpus.
The literature describes good results from the use of different reconstruction procedures in order to minimize complications after wide excision of the distal ulna .
On the other hand, some authors suggest that in oncological resection of the distal ulna, reconstruction does not improve functional outcomes, and simple resection does not increase the complication rate caused by reconstructive techniques [2, 3, 8]. Although there are no data on the maximal length of distal ulna resection achievable without functional impairment, we deem that the length of the distal ulna resection, without reconstruction implying any functional impairment, would be no more than one-third of the entire bone.
A complication of distal ulnar resection, which is not mentioned in the literature to the best of the authors’ knowledge, is myositis ossificans arising from the interosseous membrane. We believe that the micro instability of the distal ulnar stump would be the cause of bleeding and consequent myositis ossificans in our case. This has led to difficulties in differential diagnosis with parosteal osteosarcoma.
On radiological examination, the lesion of myositis ossificans should not surround the host bone, and shows a transparent line that indicates the complete separation from the cortex (zonal sign). However, the location of the myositis, the simultaneous detection of lung metastasis from the parosteal osteosarcoma and the rapid increase of the mass raised the suspicion of recurrence from the primary tumor, and justified the second en bloc resection, even with a histological diagnosis of a benign lesion.
The management of this complication led to a proximal ulnar resection. The lack of reconstruction in this resection entails more complications. The patient complained of a dorsal subluxation of the ulnar remnant during elbow flexion.
After proximal ulna resection, the radius is the only bone which supports moment forces in movements and this probably led to a fracture without a trauma, even if the resection of the cortex was less than one-fifth of the entire diameter. We suggest, in the case of proximal ulnar resection, a preventive osteosynthesis of the radius to give a better mechanical stability to this segment and to avoid a possible fracture due to high moment forces on the bone segment.
We suggest that the patient undergoes an autograft reconstruction with a vascularized fibular graft. Other biological reconstructive options could be autografts, allografts or a non-biological spacer made with Stainmann and cement to avoid gross instability. Every procedure is associated with a failure rate and complications, and the patient has to be aware of these.
In upper limb reconstructive procedures, Gebert et al. suggest the use of endoprothesis in smaller tumors, older patients and good soft tissue coverage. In the case of a large diaphyseal defect, young patients and poor soft tissue coverage, biological reconstruction should be considered. A vascularized graft could be a choice for defects of up to 6 to 8 cm. For longer defects, the reconstruction is susceptible to failure because of the lack of vascularization, and for defects greater than 12 cm, the bone graft is never completely replaced by healthy tissue and remains weaker than normal bone, increasing the risk of fracture.
For longer defects, a vascularized fibula graft (VFG) displays an increased initial graft strength and a more rapid union.
Although no final conclusion could be drawn from one case, we consider, with other authors , that, in the case of malignant tumor of the distal ulna, the achievement of good margins after resection is of primary importance. Additional reconstructive procedures impact on the morbidity and add the risk of complications that are not justified by the functional improvement; moreover, they require special technical skills and are not routinely justified for this rare condition. Afterwards, we suggest the preventive synthesis of the radius if partial osteotomy is required when the ulna is resected.
Poor soft tissue coverage is clearly the only indication, according to the authors, for a non-reconstruction technique in a longer resection.
Written informed consent was obtained from the patient for publication of this case report and any accompaining images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
magnetic resonance imaging
vascularized fibula graft.
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