Figure 1From: Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissueRNA in situ hybridization of TP53 expression for normal tissue adjacent to cancerous tissue and normal tissue adjacent to benign tissue. (A-D) show the NTAC from the thyroid, breast, liver and colon cancer samples, respectively. (A′-D′) show the NTAB. Unlike in malignant RISH, there is no clonal patch, but there is a scattered TP53-positive cell distribution, indicated by the arrow. The positive cell number and density were visualized on a Zeiss-Axiophot DM HT microscope (Zeiss-Axiophot, Oberkochen, Germany) and captured with an attached camera linked to a computer plus EZ-HYB software. NTAB: normal tissue adjacent to benign tissue; NTAC: normal tissue adjacent to cancerous tissue; RISH: RNA in situ hybridization.Back to article page