Endoscopically observable white nodule caused by distal intramural lymphatic spread of rectal cancer: a case report
© Tsumura et al.; licensee BioMed Central Ltd. 2012
Received: 16 March 2012
Accepted: 26 September 2012
Published: 11 October 2012
This report describes a case of rectal cancer with endoscopically observable white nodules caused by distal intramural lymphatic spread. A 57-year-old female presented to our hospital with frequent diarrhea and hemorrhoids. Computed tomography showed bilateral ovarian masses and three hepatic tumors diagnosed as rectal cancer metastases, and also showed multiple lymph node involvement. The patient was preoperatively diagnosed with stage IV rectal cancer. Colonoscopy demonstrated that primary rectal cancer existed 15 cm from the anal verge and that there were multiple white small nodules on the anal side of the primary tumor extending to the dentate line. Biopsies of the white spots were performed, and they were identified as adenocarcinoma. The patient underwent Hartmann’s procedure because of the locally advanced primary tumor. The white nodules were ultimately diagnosed as being caused by intramural lymphatic spreading because lymphatic permeation was strongly positive at the surrounding area. Small white nodules near a primary rectal cancer should be suspected of being intramural spreading. Endoscopic detection of white nodules may be useful for the diagnosis of distal intramural spread.
KeywordsRectal cancer White nodule Intramural spread Lymphatic permeation
To avoid local recurrence of rectal cancer, it is important to determine an appropriate distance of the distal resection margin of the tumor. Distal intramural spread is one of the crucial factors involved in making the decision about the extent of the anal resection margin [1–5]. Transrectal ultrasonography has been reported to be useful for preoperative detection of distal intramural spread . However, there are no reports concerning endoscopic detection of distal intramural metastasis. Here we present the case of a patient with rectal cancer who had endoscopically observable white nodules caused by distal intramural lymphatic spread.
The local recurrence rate of rectal cancer patients after surgery with total mesorectal excision is reported to be 6–9.7% [7–9]. To reduce local recurrence, one of the important points is to determine the appropriate distal margin. Some reports have shown that distal intramural spread was observed in 10.6-40% of rectal cancer [1–5, 10, 11]. Some reports have shown that 2 cm distance of the distal resection margin from the tumor is safe, since distal intramural spreading rarely exceeds 2 cm [2, 10, 11]. The rate of intramural spread exceeding 1 cm in rectal cancer cases is 10% , and more than 2 cm was reported in 1.3-6% of rectal cancer cases [1, 2, 10, 11]. So far, distal intramural spread is determined by pathological findings; therefore, it cannot be diagnosed prior to surgery. If preoperative detection of intramural spread becomes possible, it will be helpful for reducing the local recurrence rate.
The pattern of metastases to the anus is implanted or lymphovascular metastases . Implantation of rectal carcinoma cells has often been reported in the last half century. Rectal cancer cells are able to metastasize to the anal fistula [13, 14], biopsy wounds , suture lines [16–18], and obstructive colitis . Lymphovascular metastasis in the literature is defined as anorectal metastatic cancer with an intact anorectal epithelium . In this case, the histological findings showed that small white nodules, consisting of cancer cells, existed in the lymphatic vessels of the submucosa and muscularis mucosae, but not on the mucosa (Figure 4B). Therefore, these white spots appeared to metastasize via microlymphatic ducts and invaded the submucosa. Rectal carcinoma is able to invade and metastasize in other ways, such as direct invasion and hematogenous spread. In the present case, direct extension, intraluminal implantation, and hematogenous spread did not occur, as shown by the discontinuous spread of the tumor, no cancer cells on the mucosa, and the smaller number of venous permeations, respectively. Finally, we determined that the white nodules were caused by lymphatic invasion.
Local recurrence by lymphovascular metastasis to the anus has been shown to be uncontrollable despite wide resection . The presence of lymphovascular invasion as an independent factor for local recurrence in a multivariate analysis has been reported , implying that distal intramural lymphatic metastasis to the anal side is an important factor for local recurrence. Lymphatic spreading is characterized by massive invasion into lymphatic vessels and lymph node metastases. Therefore, excision of the primary lesion and the usual resected distal margin of the rectum are insufficient for patients with massive distal intramural lymphatic spread. Radical surgery including the metastasized lymphatic system may be required to achieve better local control. Prior to surgery, if colonoscopy reveals white nodules on the anal side of the tumor, radical surgery should be performed to avoid local recurrence.
This report presented a case of rectal cancer with white nodules on the anal side of the tumor. The white nodules were caused by distal intraluminal lymphatic spread. Endoscopic diagnosis of white nodules around the tumor may reduce local recurrence of rectal cancer.
Written consent was obtained from the patient for publication of this study and the related photos.
AT performed the surgery, literature search, and write up of the manuscript. SY initiated the concept, performed the surgery, helped in the literature search, and gave approval for the final write up. KT performed the surgery. TH helped in the revision of the article. KM helped in the revision of the article. TW helped in the revision of the article. YM helped in the revision of the article. HY contributed to the clinical management of the patient and helped in the revision of the article. All authors read and approved the final manuscript.
Writing assistance: Dr. Brian Quinn, Editor-in-Chief, Japan Medical Communication.
- Andreola S, Leo E, Belli F, Lavarino C, Bufalino R, Tomasic G, Baldini MT, Valvo F, Navarria P, Lombardi F: Distal intramural spread in adenocarcinoma of the lower third of the rectum treated with total rectal resection and coloanal anastomosis. Dis Colon Rectum. 1997, 40: 25-29. 10.1007/BF02055677.View ArticlePubMed
- Shimada Y, Takii Y, Maruyama S, Ohta T: Intramural and mesorectal distal spread detected by whole-mount sections in the determination of optimal distal resection margin in patients undergoing surgery for rectosigmoid or rectal cancer without preoperative therapy. Dis Colon Rectum. 2011, 54: 1510-1520. 10.1097/DCR.0b013e318233fc4a.View ArticlePubMed
- Scott N, Jackson P, Al-Jaberi T, Dixon MF, Quirke P, Finan PJ: Total mesorectal excision and local recurrence: a study of tumour spread in the mesorectum distal to rectal cancer. Br J Surg. 1995, 82: 1031-1033. 10.1002/bjs.1800820808.View ArticlePubMed
- Ono C, Yoshinaga K, Enomoto M, Sugihara K: Discontinuous rectal cancer spread in the mesorectum and the optimal distal clearance margin in situ. Dis Colon Rectum. 2002, 45: 744-749. 10.1007/s10350-004-6290-1. discussion 742–743View ArticlePubMed
- Zhao GP, Zhou ZG, Lei WZ, Yu YY, Wang C, Wang Z, Zheng XL, Wang R: Pathological study of distal mesorectal cancer spread to determine a proper distal resection margin. World J Gastroenterol. 2005, 11: 319-322.PubMed CentralView ArticlePubMed
- Yanagi H, Kusunoki M, Shoji Y, Yamamura T, Utsunomiya J: Preoperative detection of distal intramural spread of lower rectal carcinoma using transrectal ultrasonography. Dis Colon Rectum. 1996, 39: 1210-1214. 10.1007/BF02055110.View ArticlePubMed
- Enker WE, Thaler HT, Cranor ML, Polyak T: Total mesorectal excision in the operative treatment of carcinoma of the rectum. J Am Coll Surg. 1995, 181: 335-346.PubMed
- Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK: Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978–1997. Arch Surg. 1998, 133: 894-899. 10.1001/archsurg.133.8.894.View ArticlePubMed
- Law WL, Chu KW: Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients. Ann Surg. 2004, 240: 260-268. 10.1097/01.sla.0000133185.23514.32.PubMed CentralView ArticlePubMed
- Ueno H, Mochizuki H, Hashiguchi Y, Ishikawa K, Fujimoto H, Shinto E, Hase K: Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer. Ann Surg. 2004, 239: 34-42. 10.1097/01.sla.0000103070.13030.eb.PubMed CentralView ArticlePubMed
- Williams NS, Dixon MF, Johnston D: Reappraisal of the 5 centimetre rule of distal excision for carcinoma of the rectum: a study of distal intramural spread and of patients’ survival. Br J Surg. 1983, 70: 150-154. 10.1002/bjs.1800700305.View ArticlePubMed
- Takahashi H, Ikeda M, Takemasa I, Mizushima T, Yamamoto H, Sekimoto M, Doki Y, Mori M: Anal metastasis of colorectal carcinoma origin: implications for diagnosis and treatment strategy. Dis Colon Rectum. 2011, 54: 472-481. 10.1007/DCR.0b013e318205e116.View ArticlePubMed
- Ishiyama S, Inoue S, Kobayashi K, Sano Y, Kushida N, Yamazaki Y, Yanaga K: Implantation of rectal cancer in an anal fistula: report of a case. Surg Today. 2006, 36: 747-749. 10.1007/s00595-006-3236-3.View ArticlePubMed
- Gupta R, Kay M, Birch DW: Implantation metastasis from adenocarcinoma of the colon into a fistula-in-ano: a case report. Canadian journal of surgery Journal canadien de chirurgie. 2005, 48: 162-163.PubMed CentralPubMed
- Basha G, Ectors N, Penninckx F, Filez L, Geboes K: Tumor cell implantation after colonoscopy with biopsies in a patient with rectal cancer: report of a case. Dis Colon Rectum. 1997, 40: 1508-1510. 10.1007/BF02070721.View ArticlePubMed
- Umpleby HC, Fermor B, Symes MO, Williamson RC: Viability of exfoliated colorectal carcinoma cells. Br J Surg. 1984, 71: 659-663. 10.1002/bjs.1800710902.View ArticlePubMed
- Gertsch P, Baer HU, Kraft R, Maddern GJ, Altermatt HJ: Malignant cells are collected on circular staplers. Dis Colon Rectum. 1992, 35: 238-241. 10.1007/BF02051014.View ArticlePubMed
- Tsunoda A, Shibusawa M, Tsunoda Y, Kamiyama G, Yamazaki K, Kusano M: Effect of povidone-iodine on anastomotic tumor growth in an experimental model of colorectal cancer surgery. Anticancer Res. 1999, 19: 1149-1152.PubMed
- Mekata E, Shimizu T, Endo Y, Tani T: The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: report of a case. Surg Today. 2008, 38: 862-865. 10.1007/s00595-007-3708-0.View ArticlePubMed
- Law WL, Chu KW: Local recurrence following total mesorectal excision with double-stapling anastomosis for rectal cancers: analysis of risk factors. World J Surg. 2002, 26: 1272-1276. 10.1007/s00268-002-6560-9.View ArticlePubMed
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