From: High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma
Covariate | Univariate analysis | Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|---|
OS | RFS | OS | RFS | |||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Gender (male vs. female) | 0.941 | 0.862 | 0.939 | 0.844 | 0.887 | 0.75 | 0.876 | 0.705 |
(0.474, 1.869) | (0.504, 1.752) | (0.422, 1.861) | (0.443, 1.734) | |||||
Age (≤60 vs. >60 years) | 1.459 | 0.269 | 1.043 | 0.897 | 1.759 | 0.141 | 1.112 | 0.769 |
(0.747, 2.850) | (0.554, 1.961) | (0.829, 3.734) | (0.549, 2.251) | |||||
Tumor size (≤4 vs. 4–7 vs. >7cm) | 1.399 | 0.145 | 1.448 | 0.083 | 1 | 0.999 | 0.898 | 0.715 |
(0.890, 2.198) | (0.953, 2.199) | (0.539, 1.854) | (0.503, 1.602) | |||||
Symptoms at diagnosis | 1.951 | 0.05 | 1.605 | 0.126 | 2.35 | 0.04 | 1.745 | 0.121 |
(incidental vs. symptoms) | (1.001, 3.800) | (0.875, 2.942) | (1.038, 5.318) | (0.863, 3.527) | ||||
AJCC stage (T1 vs. T2 vs. T3-T4) | 1.325 | 0.153 | 1.351 | 0.104 | 0.96 | 0.881 | 1.123 | 0.643 |
(0.901, 1.950) | (0.940, 1.942) | (0.565, 1.633) | (0.688, 1.831) | |||||
Lymph nodal status | 1.079 | 0.725 | 1.097 | 0.637 | 0.997 | 0.989 | 0.962 | 0.861 |
(N0 vs. N1 vs. Nx) | (0.706, 1.649) | (0.746, 1.613) | (0.613, 1.620) | (0.620, 1.490) | ||||
Metastasis (M0 vs. M1) | 3.389 | 0.023 | 4.324 | 0.003 | 5.109 | 0.014 | 6.807 | 0.001 |
(1.187, 9.677) | (1.642, 11.391) | (1.390, 18.787) | (2.103, 22.035) | |||||
Histologic variant | 1.587 | 0.339 | 1.565 | 0.31 | 1.486 | 0.521 | 2.167 | 0.157 |
(clear cell vs. others) | (0.615, 4.091) | (0.659, 3.715) | (0.443, 4.981) | (0.734, 6.319) | ||||
Fuhrman’s grade | 1.363 | 0.173 | 1.268 | 0.26 | 1.316 | 0.274 | 1.105 | 0.675 |
(1 vs. 2 vs. 3 vs. 4) | (0.873, 2.130) | (0.839, 1.918) | (0.805, 2.151) | (0.693, 1.761) | ||||
CXCR4 (low vs. high) | 3.994 | 0.002 | 3.772 | 0.001 | 6.946 | <0.001 | 8.034 | <0.001 |
(1.655, 9.639) | (1.741, 8.169) | (2.498, 19.314) | (3.192, 20.221) | |||||
CXCR7 (low vs. high) | 4.465 | 0.013 | 3.195 | 0.015 | 5.506 | 0.01 | 6.059 | 0.001 |
(1.366, 14.594) | (1.254, 8.139) | (1.506, 20.129) | (2.013, 18.237) | |||||
SDF-1 (low vs. high) | 3.344 | <0.001 | 3.206 | <0.001 | 11.406 | <0.001 | 14.025 | <0.001 |
 | (1.713, 6.527) |  | (1.734, 5.928) |  | (4.718, 27.576) |  | (5.864,33.542) |  |